Improved long-term results of intensity-modulated radiotherapy for a non-endemic European nasopharyngeal carcinoma cohort: single-center retrospective study

Biopsy of cervical lymph node does not impact the survival of nasopharyngeal carcinoma

“…The widespread use of chemotherapy, MRI, and IMRT has been confirmed to significantly decrease the incidence of distant metastasis and improved survival outcomes. [14][15][16]29 As CLNB would not contribute to inferior survival outcomes, more aggressive therapy may not be required.…”

“…The introduction of intensity-modulated radiotherapy (IMRT) into clinical management has made great improvements in the survival of NPC patients. [14][15][16] Moreover, additional chemotherapy also decreased the incidence of distant metastasis and mortality of NPC. 17 However, the current recommendation regarding the CLNB remains controversial in various clinical practice guidelines of NPC, including National Comprehensive Cancer Network (NCCN) Guidelines in 2020, 18 European Society for Medical Oncology (ESMO)-European Rare CANcer (EURACAN) Clinical Practice Guideline in 2021, 19 Guidelines of Chinese Society of Clinical Oncology (CSCO) in 2020, 20 Spanish Society of Medical Oncology (SEOM) Clinical Guideline in 2017, 21 and the United Kingdom National Multidisciplinary Guidelines in 2016.…”