Improved loquat (Eriobotrya japonica Lindl.) cultivars: Variation of phenolics and antioxidative potential

Ferreres, Federico; Gomes, Daniela; Valentão, Patrı́cia; Gonçalves, Rui F.; Pio, Rafael; Chagas, Edvan Alves; Seabra, Rosa M.; Andrade, Paula B.

doi:10.1016/j.foodchem.2008.10.065

Cited by 134 publications

(89 citation statements)

References 24 publications

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“…These results are in agreement with the previous report [1,24]. However, their compounds were much lower in LTE ( Figure 5A-b), and finally disappeared in the C and C2 fractions.…”

Section: Discussionsupporting

confidence: 94%

Antioxidant and anti-inflammatory activities of loquat (Eriobotrya japonica) tea

Zar

Sakao²,

Hashimoto

et al. 2013

FFHD

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Background: Fresh loquat leaves contain several kinds of flavonoids and have been reported to have preventive effects against some human diseases such as diabetes, coughs and ulcers,. Recently, fresh loquat leaves in Japan were processed to a beverage, called loquat tea, after the fresh leaves are roasted at 350C for 30 minutes. However, the scientific evidence supporting the functions of these processed leaves is still minimal.Objective: The aim of this study is to investigate the antioxidant and anti-inflammatory activities of roasted loquat tea extract (LTE) in vitro and in culture cells. Methods:Bioactive fractions of LTE were separated by column chromatograph. Antioxidant activities were determined by DPPH and ROS assay. Pro-inflammatory mediators cyclooxygenase-2 (COX-2) and prostaglandin E 2 (PGE 2 ) were determined by Western blot and ELISA assay, respectively. Chemical quantification and characterization were analyzed by HPLC, FR-IR, and NMR. Phenolic content was measured by Folin-Ciocalteu assay. Results:The results showed that loquat tea extract (LTE) possessed stronger DPPH scavenging activity than fresh. Cellular data revealed that LTE inhibited the production of reactive oxygen species (ROS), and further suppressed the production of COX-2 and PGE 2 in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Chemical quantification and characterization data indicated that LTE contained new bioactive phenolic components that were produced from the roasting processes of fresh loquat leaves. Conclusions: Loquat tea made from roasted loquat leaves contained new bioactive phenolic compounds that contribute to its antioxidant and anti-inflammatory activities.

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“…These results are in agreement with the previous report [1,24]. However, their compounds were much lower in LTE ( Figure 5A-b), and finally disappeared in the C and C2 fractions.…”

Section: Discussionsupporting

confidence: 94%

Antioxidant and anti-inflammatory activities of loquat (Eriobotrya japonica) tea

Zar

Sakao²,

Hashimoto

et al. 2013

FFHD

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“…The free radical activity with DPPH as a free radical was determined following a modified method 17,18 . Different concentrations (1-32 µg/ml) of the sample and AA, as positive control, were prepared.…”

Section: Radical Dpph Scavenging Activitymentioning

confidence: 99%

Antioxidant activity of flavonoids from leaves of Jatropha curcas

Huang¹,

Guo²,

Fu³

et al. 2014

ScienceAsia

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The objective of this study was to characterize the antioxidant properties of ethanol extracted from leaves of Jatropha curcas and to determinate the compounds. The IC 50 values of DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt) were found to be 7.47 and 6.6 µg/ml, respectively, for the extracts. The reducing power of the extracts increased from 0.09 to 0.16, respectively, for 1-32 µg/ml of standard reagent. The assignment of the flavone compounds using HPLC-DAD-MS n was based on the evaluation of their UV-Vis absorption maxima (λmax) and mass spectral analyses. Tentatively, 4 compounds (orientin, vitexin, isovitexin, rhoifolin) were identified.

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“…Phytochemical analysis of Eriobotrya japonica has shown the presence of a number of compounds having antioxidant activity. The HPLC-DAD-ESI-MS/MS screening of the hydro-methanolic extracts of loquat leaves, peel and flesh revealed the presence of several phenolic compounds, mostly hydroxycinnamic acid derivatives and flavonoid glycosides [13]. But, as far as we know, on the Eriobotrya japonica flowers no study has been conducted.…”

Section: Modeling Of Mercury Accumulation In Liver Tissuesmentioning

confidence: 99%

“…Its leaves have been used for treatment of skin diseases and diabetes [11], chronic bronchitis, coughs, phlegm, ulcers and cancer [12]. Eriobotrya japonica (Loquat) is full of phenolics and antioxidant compounds [13]. Flavonoids and phenolic compounds are secondary metabolites, affluent in the plant kingdom and effective in human health, and decrease the risk of several diseases by reducing oxidative stress [14].…”

mentioning

confidence: 99%

Effects of Eriobotrya japonica (Lindl.) flower extracts on mercuric chloride-induced hepatotoxicity in rats

et al. 2012

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Mercury (II) is an important factor in hepatotoxicity that can enter the body through marine diets and amalgams. In the present study, the protective effect of the Eriobotrya japonica flower extract (EJFE) on HgCl 2 -induced hepatotoxicity was investigated. Five mg/kg of mercuric chloride in drinking water was given to rats either with saline or EJFE (100 and 200 mg/kg as intraperitoneal (IP)) for 30 d. The mercury levels in different groups of liver tissues of the rats were measured with flameless atomic absorption spectroscopy (F-AAS). Also, mercury accumulation in the liver of the rats was modeled by using a parallel chemical kinetic model. The results showed that HgCl 2 -induced oxidative damage led to a significant decrease in glutathione (GSH) and the total antioxidant capacity (TAC) levels, and to a significant increase in lipid peroxidation level. Accumulated mercury was 14.47% more in the livers of the stress groups than in those of the control groups (P<0.001), whereas the amount of Hg was adjusted to 13.49% and 13.93% in groups treated with 100 and 200 mg/kg of EJFE respectively, as compared with stress groups (P<0.001). HPLC analysis of EJFE revealed that hesperetin and gallic acid are the major antioxidants in EJFE. Results demonstrate that flowers of the Eriobotrya japonica cause a significant protection against HgCl 2 induced hepatotoxicity in all diagnostic parameters by strengthening the antioxidant defense mechanisms and they may have a therapeutic function in free radical mediated diseases. mercury, oxidative stress, hepatotoxic, Eriobotrya japonica, antioxidant Citation:Esmaeili A H, Khavari-Nejad R A, Hajizadeh Moghaddam A, et al. Effects of Eriobotrya japonica (Lindl.) flower extracts on mercuric chloride-induced hepatotoxicity in rats.

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Improved loquat (Eriobotrya japonica Lindl.) cultivars: Variation of phenolics and antioxidative potential

Cited by 134 publications

References 24 publications

Antioxidant and anti-inflammatory activities of loquat (Eriobotrya japonica) tea

Antioxidant and anti-inflammatory activities of loquat (Eriobotrya japonica) tea

Antioxidant activity of flavonoids from leaves of Jatropha curcas

Effects of Eriobotrya japonica (Lindl.) flower extracts on mercuric chloride-induced hepatotoxicity in rats

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