Improved method to induce superovulation in cattle using Human Menopausal Gonadotropin (HMG)

Lauria, A.; Oliva, O.; Genazzani, Andrea Riccardo; Crémonesi, F.; Crotti, Stefania; Barbetti, Margherita

doi:10.1016/0093-691x(82)90013-9

Cited by 19 publications

(7 citation statements)

References 5 publications

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“…The superovulatory response in the Treatment group was not different from that observed in the Control group, demonstrating that hMG administered once daily over a 4 -day period was effective for stimulating multiple ovulations in sheep. In this context, our observations agreed with hMG studies involving cattle and sheep (Lauria et al, 1982;Schiewe et al, 1990;Scudamore et al, 1991;Sugano et al, 2001). FSH and hMG stimulated an average of 10.4…”

Section: Discussionsupporting

confidence: 89%

“…and 11.1 transferable embryos per ewe, respectively, which was equal or greater than the response reported by other researchers using FSH (Bartlewski et al, 2017;Bettencourt et al, 2008;Forcada et al, 2011;King et al, 2022;Menchaca et al, 2009;Quan et al, 2011). In cattle, hMG can reduce ovulatory variability among individual animals (Lauria et al, 1982), an observation we failed to detect in sheep. Furthermore, the structures recovered, transferable embryos, degenerated embryos, unfertilized oocytes, and pregnancy rate and lambing rate after embryo transfer were similar in hMG and FSH.…”

Section: Discussioncontrasting

confidence: 70%

“…Even, it has been reported that hMG induced a significantly higher ovulation rate as well as better embryo quality than did FSH in cattle (Sugano et al, 1995(Sugano et al, , 1999(Sugano et al, , 2001. In 1982, hMG was first reported as an effective gonadotrophic hormone for inducing superovulation and demonstrated the efficacy of hMG and investigated the optimal dose in cattle (Lauria et al, 1982). It was reported that administration of 900 IU of hMG twice daily for four consecutive days resulted in a significant increase in transferable embryos compared with FSH treatment and that the percentage of embryos of excellent quality was higher in the hMG -treated group than in the FSH -treated group in Japanese Black cattle (Sugano et al, 2001).…”

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confidence: 99%

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Potential role for human menopausal gonadotropin in ovine superovulatory regimens during the breeding season

Zhang

Liu

et al. 2023

Reprod Domestic Animals

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Human menopausal gonadotrophin (hMG) has been reported to produce a comparable superovulatory response to that of follicle stimulating hormone (FSH). Furthermore, hMG has a long half‐life as compared with FSH. The present study was designed to compare hMG administered once daily and FSH administered twice daily over a 4 ‐ day period on superovulatory response of Suffolk ewes. During the mid‐luteal phase, twenty‐four Suffolk donor ewes received intravaginal sponges at day 0 for 12 days. The superovulatory regimens in the Control group (n = 12) and the Treatment group (n = 12) consisted of eight injections of FSH given at twice daily and four injections of hMG given at once daily, respectively. At day 13, the donor ewes were subjected to laparoscopic insemination. Embryos were recovered, classified, and transferred to recipient ewes at day 19. Pregnancy status was determined by ultrasound examination 40 days after transfer. Lambing rate was calculated after all the ewes had delivered. No significant differences were observed between the two groups in terms of the structures recovered, transferable embryos, degenerated embryos, unfertilized oocytes, pregnancy rate and lambing rate. The results showed that once daily injection of hMG can produce a comparable superovulatory response and embryo transfer outcomes to those obtained by twice daily injection of FSH over a 4 ‐ day period. It is feasible that hMG is used to replace FSH and reduce the number of injection treatments in ovine superovulatory regimens.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 70%

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confidence: 99%

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Potential role for human menopausal gonadotropin in ovine superovulatory regimens during the breeding season

Zhang

Liu

et al. 2023

Reprod Domestic Animals

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“…However, the excellent quality embryos were significantly higher (P < 0.05) in both the FSH-P and FSH-O treatment groups than in the HMG group. The major factors responsible for the low yield of transferable embryos in HMG group may be due to the presence of prematurely regressing corpus luteum and early onset of oestrus in HMG treated goats (Lauria et al, 1982 andIheukwumere, 2004). The higher number of transferable embryos in FSH groups might be due to relative increase in progesterone level after oestrus till the day of embryo collection (Britt and Gaska, 1998).…”

Section: In Goatsmentioning

confidence: 99%

The Effects Of Different Gonadotrophin Treatments On The Embryo Generation And Quality Of Embryos In West African Dwarf Goats

Iheukwumere¹

2008

Journal of Agriculture and Social Research (JASR)

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The effects of Ovine FSH, Porcine FSH (FSH-P) and HMG treatments on embryo generation and embryo quality were studied in West African dwarf goats The results on the number of corpora lutea (CL) on the ovary was . The number of non-transferable embryos showed no significant difference (P > 0.05) between the treatment groups. The results of this study indicated that FSH-O is the gonadotrophin of choice for goat superovulation.

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“…In 1982, Lauria, et al [1,2] reported the efficiency of h u m a n Me n o p a u s a l G o n a d o t r o p h i n ( h M G ) f o r superovulation in cows for the first time. At the present time, pregnant mare's serum gonadotrophin (PMSG) and follicle stimulating hormone (FSH) are most widely used for the superovulation of Japanese Black cows in Japan.…”

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confidence: 99%

Superovulation with Human Menopausal Gonadotrophin in Japanese Black Cows

Sugano¹,

Shinogi²

2002

J.Mamm.Ova.Res.

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Abstract:The aim of this study is to induce effective superovulation in Japanese Black cows with hMG and to produce high-quality embryos in a short interval of superovulation treatment. In the first superovulation treatment, a total of 750 IU hMG was used and after collection, 50 ml of iodine was infused into the uterus and a 25 ml PGF 2α intramuscular injection was also given. After confirming the return of oestrous, a second treatment was conducted with a total of 600 IU hMG. Although the total number of collected ova/embryos and transferable embryos was less in the second treatment than in the first one, the ratio of transferable and excellent embryos was considered to be high. In conclusion, it was indicated that 600 IU hMG is effective for superovulation and that iodine preparation and PGF 2α produce high-quality embryos in a short interval of superovulation treatment.

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Improved method to induce superovulation in cattle using Human Menopausal Gonadotropin (HMG)

Cited by 19 publications

References 5 publications

Potential role for human menopausal gonadotropin in ovine superovulatory regimens during the breeding season

Potential role for human menopausal gonadotropin in ovine superovulatory regimens during the breeding season

The Effects Of Different Gonadotrophin Treatments On The Embryo Generation And Quality Of Embryos In West African Dwarf Goats

Superovulation with Human Menopausal Gonadotrophin in Japanese Black Cows

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