This paper deals with the dynamic response of a flat roof which is subjected to a moving microburst. Taking the fluid-structure interaction into account, a methodology for the numerical simulation of the time histories of wind pressures on the roof is proposed by retrofitting the usage of deterministic-stochastic hybrid model. Whereby, the dynamic response of the roof could be computed. Gust-front factor, which is defined as the ratio of the maximum response caused by downburst to that caused by atmospheric boundary layer wind, is employed herein for dynamical analysis. The results indicate that the ratio of jet velocity to translating speed of the microburst has a significant influence on the peak value of the wind pressure coefficient. It is found that the gust-front factor decreases with the increase of jet velocity of the microburst, and increases with the first natural frequency of the roof.