Improved nerve regeneration through piezoelectric vinylidenefluoride-trifluoroethylene copolymer guidance channels

Fine, Eric G.; Valentini, Robert F.; Bellamkonda, Ravi; Aebischer, Patrick

doi:10.1016/0142-9612(91)90029-a

Cited by 120 publications

(70 citation statements)

References 17 publications

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“…The hydrophilic surface and the negative charge of this material would allow for elongation of the attached proteins, and therefore could be a reason the cells have high proliferation. The negative charge could also be a reason for the improved cell attachment and lamellipodia extensions for the PC12, as was also found with (Fine et al, 1991). However (Makohliso et al, 1993) showed evidence that CNS neurite growth was more sensitive to charge and favored a more positively charged environment, and this may be a reason for the decreased H4 and lamellipodia attachment.…”

Section: Discussionmentioning

confidence: 77%

“…Growth cone formation and filopodia/ lamellipodia guidance have been shown to favor a more hydrophobic surface (Clark et al, 1993). Neurite formation and extension are also influenced by substrate charge, with this growth favoring positive charge over negative charge, and neutral charges produce almost no neurite outgrowth (Fine et al, 1991;Makohliso et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

AFM and Cell Staining to Assess the In Vitro Biocompatibility of Opaque Surfaces

Frewin¹,

Oliveros²,

Weeber³

et al. 2012

Atomic Force Microscopy Investigations Into Biology - From Cell to Protein

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

AFM and Cell Staining to Assess the In Vitro Biocompatibility of Opaque Surfaces

Frewin¹,

Oliveros²,

Weeber³

et al. 2012

Atomic Force Microscopy Investigations Into Biology - From Cell to Protein

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“…FTIR spectra of electrospun samples show that the crystallization of the polymer occurs in the ferroelectric phase ( figure 7b) due to the presence of the absorption band at 840 cm -1 , characteristic of this phase and the absence of absorption modes of the -phase of PVDF that occur at 855, 795 and 766 cm -1 ) or -phase (833, 812 and P(VDF-TrFE) is therefore obtained by electrospinning in the electroactive phase, showing a large potential for biomedical and tissue engineering applications, especially for bone repair [30], nerve guidance [31,32] or even cochlea reconstruction [33].…”

Section: Resultsmentioning

confidence: 99%

Fiber average size and distribution dependence on the electrospinning parameters of poly(vinylidene fluoride–trifluoroethylene) membranes for biomedical applications

et al. 2012

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Poly(vinylidene fluoride-trifluoethylene), P(VDF-TrFE), electrospun membranes were obtained from a mixture of dimethylformamide (DMF) and methylethylketone (MEK) solvents. The inclusion of MEK to the solvent system promotes a faster solvent evaporation allowing complete polymer crystallization during the jet travelling between the tip and the grounded collector.The main electrospinning processing parameters were systematically changed to study their influence on fiber dimensions and distribution. Applied voltage and inner needle diameter do not have large influence on the electrospun fiber average diameter but in the fiber diameter distribution. On the other hand, increasing the distance between the needle tip and the collector gives origin to fibers with larger average diameter. Independently on the processing conditions, all mats are produced in the electroactive phase of the polymer. Further, MC-3T3-E1cell adhesion is not inhibited by the fiber mats preparation, showing their potential use for biomedical applications.

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“…Their results showed that piezoelectric nerve guidance channels enhance peripheral nerve regeneration and provide a tool to investigate the influence of electrical activity on nerve regeneration. In yet another study, Fine et al (1991) synthesized tubular nerve guidance using a vinylidenefluoride-trifluoroethylene copolymer synthesized by a melt-erosion process. Piezoelectrically active vinylidenefluoride-trifluoroethylene copolymer tubes were found to significantly enhance the nerve regeneration process.…”

Section: Piezoelectric Polymeric Materialsmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

616

389

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

show abstract

Improved nerve regeneration through piezoelectric vinylidenefluoride-trifluoroethylene copolymer guidance channels

Cited by 120 publications

References 17 publications

AFM and Cell Staining to Assess the In Vitro Biocompatibility of Opaque Surfaces

AFM and Cell Staining to Assess the In Vitro Biocompatibility of Opaque Surfaces

Fiber average size and distribution dependence on the electrospinning parameters of poly(vinylidene fluoride–trifluoroethylene) membranes for biomedical applications

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

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