Improved Neuroprotection with Melatonin-Augmented Hypothermia vs Hypothermia Alone in a Perinatal Asphyxia Model: a Randomized Study

Powell, Elizabeth M.; Faulkner, Stuart; Bainbridge, Alan; Kereyni, A; Kelen, D; Chandrasekaran, M; Lecky-Thompson, L; Price, DL; Cady, EB; Raivich, Gennadij; Golay, Xavier; Robertson, Nicola J.

doi:10.1038/pr.2011.292

Cited by 2 publications

(1 citation statement)

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“…Early post-hypoxia-ischemia administration of phenobarbital may augment the neuroprotective efficacy of therapeutic hypothermia (Barks et al, 2010) and some hormones have a neuroprotective effect in augmenting hypothermia protection. Melatonin augmented hypothermic neuroprotection in a piglet model of perinatal asphyxia (Powell et al, 2011). Exendin-4 is an analog of the human glucagon-like peptide-1 (GLP-1) gut hormone peptide.…”

Section: Hypothermia Combined With Other Neuroprotective Methodsmentioning

confidence: 99%

Neuroprotection by Therapeutic Hypothermia

et al. 2019

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Hypothermia therapy is an old and important method of neuroprotection. Until now, many neurological diseases such as stroke, traumatic brain injury, intracranial pressure elevation, subarachnoid hemorrhage, spinal cord injury, hepatic encephalopathy, and neonatal peripartum encephalopathy have proven to be suppressed by therapeutic hypothermia. Beneficial effects of therapeutic hypothermia have also been discovered, and progress has been made toward improving the benefits of therapeutic hypothermia further through combination with other neuroprotective treatments and by probing the mechanism of hypothermia neuroprotection. In this review, we compare different hypothermia induction methods and provide a summarized account of the synergistic effect of hypothermia therapy with other neuroprotective treatments, along with an overview of hypothermia neuroprotection mechanisms and cold/hypothermia-induced proteins.

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Section: Hypothermia Combined With Other Neuroprotective Methodsmentioning

confidence: 99%

Neuroprotection by Therapeutic Hypothermia

et al. 2019

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Bench to Cribside: the Path for Developing a Neuroprotectant

Ramanantsoa

Fleiss

Bouslama

et al. 2012

Transl. Stroke Res.

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The consequences of perinatal brain injury include immeasurable anguish for families and substantial ongoing costs for care and support of effected children. Factors associated with perinatal brain injury in the preterm infant include inflammation and infection, and with increasing gestational age, a higher proportion is related to hypoxic-ischemic events, such as stroke and placental abruption. Over the past decade, we have acquired new insights in the mechanisms underpinning injury and many new tools to monitor outcome in perinatal brain injury in our experimental models. By embracing these new technologies, we can expedite the screening of novel therapies. This is critical as despite enormous efforts of the research community, hypothermia is the only viable neurotherapeutic, and this procedure is limited to term birth and postcardiac arrest hypoxic-ischemic events. Importantly, experimental and preliminary data in humans also indicate a considerable therapeutic potential for melatonin against perinatal brain injury. However, even if this suggested potential is proven, the complexity of the human condition means we are likely to need additional neuroprotective and regenerative strategies. Thus, within this review, we will outline what we consider the key stages of preclinical testing and development for a neuroprotectant or regenerative neurotherapy for perinatal brain injury. We will also highlight examples of novel small animal physiological and behavioral testing that gives small animal preclinical models greater clinical relevance. We hope these new tools and an integrated bench to cribside strategic plan will facilitate the fulfillment of our overarching goal, improving the long-term brain health and quality of life for infants suffering perinatal brain injury.

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Improved Neuroprotection with Melatonin-Augmented Hypothermia vs Hypothermia Alone in a Perinatal Asphyxia Model: a Randomized Study

Cited by 2 publications

References 0 publications

Neuroprotection by Therapeutic Hypothermia

Neuroprotection by Therapeutic Hypothermia

Bench to Cribside: the Path for Developing a Neuroprotectant

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