Improved nitrogen metabolism in rats fed on lipid-rich liquid diets

Estornell, Ernesto; Barber, Teresa; Cabo, J

doi:10.1079/bjn19940144

Cited by 12 publications

(14 citation statements)

References 45 publications

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“…The marked N 2 retention was due to a decrease in amino acid catabolism and in urea production by the liver (Sadhu, 2010). Therefore daily N 2 retention was greatly enhanced in these animals which is in agreement with the known protein-sparing effect of fat (excess dietary fats spare or retain the body protein) (Estornell et al, 1994).…”

Section: Discussionsupporting

confidence: 81%

Effect of grapefruit juice and sibutramine on body weight loss in obese rats

Farouk¹,

Sawsan²,

Bahia³

et al. 2015

Afr. J. Pharm. Pharmacol.

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Grapefruit (Citrus Paradise, family Rutaceae) is a citrus fruit that is low in calories and rich in dietary fibers. Sibutramine (Sibutramine hydrochloride monohydrate) is an anti-obesity drug that enhances satiety. The effect of grapefruit juice and sibutramine on body weight and neurotransmitters controlling appetite was investigated in obese rats. Rats were assigned to two dietary groups for 3 weeks; control group (n=6) was fed commercial standard pellets diet and obese group (n=24) was fed cafeteria diet (hypercaloric diet consisting of highly palatable food). The effect of sibutramine and grapefruit juice was studied on obese rats. Statistical difference and interactions were evaluated through one-way analysis of variance test (one-way ANOVA) followed by Dunnett's test was used for means of different groups. For all statistical tests done, a 0.05 level of probability was used as the criterion for significance. Grapefruit juice produced its weight reduction effect after 1 week of administration and lasted till the end of the experiment and did not affect brain neurotransmitters. Sibutramine produced its weight reduction effect after 1 week of administration and lasted for only 2 weeks and produced an increase in brain noradrenaline while grapefruit juice produced its effect from the first week till the end of the study. It can be concluded that grapefruit juice is better than sibutramine since its effect lasted till the end of the experiment and also did not affect brain noradrenaline.

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Section: Discussionsupporting

confidence: 81%

Effect of grapefruit juice and sibutramine on body weight loss in obese rats

Farouk¹,

Sawsan²,

Bahia³

et al. 2015

Afr. J. Pharm. Pharmacol.

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“…Additionally, OLE supplementation increased plasma urea concentration. High-fat diet feeding decreased urea synthesis in rats (35,36) due to reduced activities of all the enzymes of the urea cycle (35). These results along with improved glucose metabolism indicate that OLE attenuated the diet-induced metabolic deterioration.…”

Section: Discussionmentioning

confidence: 67%

Olive Leaf Extract Attenuates Cardiac, Hepatic, and Metabolic Changes in High Carbohydrate–, High Fat–Fed Rats

Poudyal

Campbell

Brown

2010

The Journal of Nutrition

244

226

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Olive oil, an important component of the Mediterranean diet, produces cardioprotective effects, probably due to both oleic acid and the polyphenols such as oleuropein and hydroxytyrosol. Our aim in this study was to assess whether a polyphenol-enriched extract from the leaves of Olea europaea L. with oleuropein as the major component attenuated the cardiovascular, hepatic, and metabolic signs of a high-carbohydrate, high-fat (HCHF) diet (carbohydrate, 52%; fat, 24%, 25% fructose in drinking water) in rats. Male Wistar rats were fed either a cornstarch diet (CS) or a HCHF diet for a total of 16 wk. Diets of the treatment groups [CS+olive leaf extract (OLE) and HCHF+OLE] were supplemented with 3% OLE after 8 wk of being fed their respective CS or HCHF diets for a further 8 wk. After 16 wk, HCHF rats developed signs of metabolic syndrome, including elevated abdominal and hepatic fat deposition, collagen deposition in heart and liver, cardiac stiffness, and oxidative stress markers (plasma malondialdehyde and uric acid concentrations), with diminished aortic ring reactivity, abnormal plasma lipid profile, impaired glucose tolerance, and hypertension. Compared with HCHF rats, those in the HCHF+OLE group had improved or normalized cardiovascular, hepatic, and metabolic signs with the exception of elevated blood pressure. These results strongly suggest that an OLE containing polyphenols such as oleuropein and hydroxytyrosol reverses the chronic inflammation and oxidative stress that induces the cardiovascular, hepatic, and metabolic symptoms in this rat model of diet-induced obesity and diabetes without changing blood pressure.

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“…More importantly, L. stoechas supplementation, protected against alloxan-induced decrease of plasma uric acid concentration as one of the major endogenous water-soluble antioxidants [49], as well as tissue malondialdehyde increase, as marker of lipid peroxidation [50]. We also showed that alloxan administration decreased antioxidant enzymes activities such as SOD and CAT.…”

Section: Discussionmentioning

confidence: 69%

Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats

et al. 2013

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BackgroundThe present study described the phytochemical profile of Lavandula stoechas essential oils, collected in the area of Ain-Draham (North-West of Tunisia), as well as their protective effects against alloxan-induced diabetes and oxidative stress in rat.MethodsEssential oils samples were obtained from the aerial parts of the plant by hydrodistillation and analyzed by GC–MS. Rats were divided into four groups: Healthy Control (HC); Diabetic Control (DC); Healthy + Essential Oils (H + EO) and Diabetic + Essential Oils (D + EO).Antidiabetic and antioxidant activities were evaluated after subacute intraperitoneally injection of Lavandula stoechas essential oils (50 mg/kg b.w., i.p.) to rats during 15 days.ResultsThe principal compounds detected are: D-Fenchone (29.28%), α-pinene (23.18%), Camphor (15.97%), Camphene (7.83%), Eucapur (3.29%), Limonene, (2.71%) Linalool, (2.01%) Endobornyl Acetate (1.03%). The essential oils also contained smaller percentages of Tricyclene, Cymene, Delta-Cadinene, Selina-3,7(11)-diene. Furthermore, we found that Lavandula stoechas essential oils significantly protected against the increase of blood glucose as well as the decrease of antioxidant enzyme activities induced by aloxan treatment. Subacute essential oils treatment induced a decrease of lipoperoxidation as well as an increase of antioxidant enzyme activities.ConclusionsThese findings suggested that lavandula stoechas essential oils protected against diabetes and oxidative stress induced by alloxan treatment. These effects are in partly due to its potent antioxidant properties.

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Improved nitrogen metabolism in rats fed on lipid-rich liquid diets

Cited by 12 publications

References 45 publications

Effect of grapefruit juice and sibutramine on body weight loss in obese rats

Effect of grapefruit juice and sibutramine on body weight loss in obese rats

Olive Leaf Extract Attenuates Cardiac, Hepatic, and Metabolic Changes in High Carbohydrate–, High Fat–Fed Rats

Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats

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