2019
DOI: 10.1002/jbm.b.34426
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Improved oral bioavailability of repaglinide, a typical BCS Class II drug, with a chitosan‐coated nanoemulsion

Abstract: The aim of the present study was to develop modified nanoemulsions to improve the oral bioavailability and pharmacokinetics of a poor water‐soluble drug, repaglinide (RPG). The repaglinide‐loaded nanoemulsions (RPG‐NEs) were prepared from olive oil as internal phase, span 80, tween 80, and poloxamer 188 as emulsifiers, using homogenization technique. The mean droplet size, zeta potential, and entrapment efficiency of RPG‐NEs were 86.5 ± 3.4 nm, −33.8 ± 2.1 mV, and 96.3 ± 2.3%, respectively. The chitosan‐coated… Show more

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Cited by 23 publications
(18 citation statements)
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References 45 publications
(61 reference statements)
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“…TCMSP provides comprehensive information about components in Chinese herbs, while TCMID provides information on all aspects of traditional Chinese medicines, including herbs and herbal ingredients. Oral bioavailability (OB), which is the percentage of an orally administered drug that reaches the systemic circulation, reflects the degree of absorption and utilization of drugs in the body [ 23 ]. The drug-likeness (DL) value reflects the structural similarity between the compound and drug molecule, so the DL compounds are more likely to display suitable pharmacodynamic and pharmacokinetic properties [ 24 ].…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…TCMSP provides comprehensive information about components in Chinese herbs, while TCMID provides information on all aspects of traditional Chinese medicines, including herbs and herbal ingredients. Oral bioavailability (OB), which is the percentage of an orally administered drug that reaches the systemic circulation, reflects the degree of absorption and utilization of drugs in the body [ 23 ]. The drug-likeness (DL) value reflects the structural similarity between the compound and drug molecule, so the DL compounds are more likely to display suitable pharmacodynamic and pharmacokinetic properties [ 24 ].…”
Section: Methodsmentioning
confidence: 99%
“…TCMSP provides comprehensive information about components in Chinese herbs, while TCMID provides information on all aspects of traditional Chinese medicines, including herbs and herbal ingredients. Oral bioavailability (OB), which is the percentage of an orally administered drug that reaches the systemic circulation, reflects the degree of absorption and utilization of drugs in the body [23].…”
Section: Chemical Compounds In Dangshenmentioning
confidence: 99%
“…The oral route is commonly used for drug delivery because of its safety [1], comfort [2], minimum effort [3], and greater patient compliance [4]. However, many drugs have difficulty in developing as oral dosage forms because of their low solubility, low permeability [6], poor bioavailability, delayed onset of action, high inter/intra subject variability [5], and lack of dose linearity [6].…”
Section: Introductionmentioning
confidence: 99%
“…Low solubility-high permeability [3]; Class III. High solubility-low permeability [4]; Class IV. Low solubility low permeability [10].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation