The rapid development of virtual reality and augmented reality technology has brought significant changes to many industries in modern society. In the field of product packaging design, the use of virtual reality and augmented reality technology in product packaging design is becoming more common in the field. Researchers are exploring the use of VR and AR technology in children’s drug packaging, employing augmented reality research that leverages natural features and artificial recognition to construct a model of children’s drug packaging that incorporates VR and AR technology. We analyze the impact of VR+AR on children’s drug packaging. Consumers’ main requirements for children’s drug packaging are bright, strong, practical, fun, novelty, and ease of understanding. The paper’s model, sample Z, ranks 5th in market competitiveness and 1st in technical competitiveness, outperforming competitors A, B, C, and D. This suggests that VR+AR children’s drug packaging still needs improvement in market competitiveness despite its high technical content. In descending order, the design evaluation dimensions score the VR+AR children’s drug packaging as follows: vivid picture (3.193)> texture (3.154) > easy to hold (3.142) > Moderate capacity (3.129) > simple and generous (3.105) > conform to the production process (3.047) > harmonious color (3.044) > convenient for transportation (3.028) > low production cost (3.012). The average score for each dimension of the VR+AR children’s drug packaging experience is approximately 4.46 points.