Improved osseointegration of 3D printed Ti-6Al-4V implant with a hierarchical micro/nano surface topography: An in vitro and in vivo study

Additive manufacturing of Ti6Al4V alloy via electron beam melting for the development of implants for the biomedical industry

“…11.3. Case study 3: implant surface modification to improve bioactivity Ren et al [357] presented a method that sought to improve the bioactivity and osteogenesis of EBM-manufactured Ti6Al4V implants by fabricating a micro/nano topography on their surface. AM comprises promising techniques in the field of tissue engineering, in that they make it possible to prototype implants using titanium and its alloys.…”

“…Nevertheless, the biological properties of this metal do not allow its direct adhesion to the bone tissue. For this reason, the authors of [357] proposed to modify the surface of EBM-manufactured Ti-6Al-4V implants via anodic oxidation and ultrasonic-assisted acid etching to remove residual powders and produce micro holes on the implants' surface (see Figure 16). They reported important findings from the in vitro and in vivo experiments they conducted.…”

Advances in implant surface modifications to improve osseointegration

“…Methods such as electrically-assisted ultrasonic nanocrystal surface modification (EA-UNSM) 112 may be useful for this purpose. Alternatively, as reported by Ren et al 103 , a layered micro/nano structure can be produced on 3D-printed Ti6Al4V implant surfaces by combining ultrasonic acid etching with AO. This surface promoted the proliferation and osteogenic differentiation of MC3T3-E1 cells by enhancing the surface hydrophilicity and bioactivity compared with the untreated implant, and also increased bone formation and osseointegration in a rat femoral defect model.…”

Effect of Different Surface Designs on the Rotational Resistance and Stability of Orthodontic Miniscrews: A Three-Dimensional Finite Element Study

“…Orthodontic miniscrews and dental implants share similarity in that they both are implanted into alveolar bone consisting of a cortical outer layer and a trabecular inner layer. The distinctive and critical feature of dental implants is that they are designed to integrate with the bone to achieve long term stabilization, which is called as osseointegration [7][8][9]. Researchers have tried to improve bone-to-implant contact by modification of the surface characteristics of dental implants.…”