Improved outcomes with oral tongue squamous cell carcinoma in Finland

Mroueh, Rayan; Haapaniemi, Aaro; Grénman, Reidar; Laranne, Jussi; Pukkila, Matti; Almangush, Alhadi; Salo, Tuula

doi:10.1002/hed.24744

Cited by 41 publications

(59 citation statements)

References 28 publications

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“…In several studies, preference for males varied among 48% and 86.4% [18][19][20][21][22][23] and the male frequency we found (53.3%) is within the above-mentioned range. In the literature, mean age is widely variable, it was from 64.3 to 47.5 years, 18,[21][22][23][24] and in our study, it was slightly lower (63.9 years).…”

Section: Agesupporting

confidence: 82%

“…An unexpected result was that in our study, the MDSCC was the most common of the analyzed tumors (56.7%), contrasting with previous data From Finland and India reporting that WDSCC was the most frequent SCCT. 20,23 50% of the analyzed patients were males with a mean age of 63.1 years and interestingly, 35.3% of the SCCs were in BT. BT located tumors were more frequent than previously published and as it was stated by Westra et al, 2 this finding could be related with the increase of HPV infection.…”

Section: Tnm Classificationmentioning

confidence: 92%

“…30,31 The mean age of 65.7 years detected in this study, was similar to previously reported data. 8,9,10,11,12,20,28,32…”

Section: Microscopic Differentiationmentioning

confidence: 99%

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Squamous cell carcinoma of the tongue in patients older than 45 years

et al. 2018

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This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Complete data from 60 cases were evaluated. They were more common in males (mean age = 63.9 years). Unexpectedly a high rate of tumors (38.3%) were in the base of the tongue (BT). Moderately and poorly differentiated SCCT were the most common. 16.7% presented lymph node invasion, 15% were recurrent tumors and BT carcinomas recurred more frequently. A high rate (81.7%) were stage II and 48.3% were low-risk patients. SCCTs in the studied population displayed different clinico-pathological and behavioral features compared with worldwide data. Our results suggest that BT tumors should be treated more aggressively than those in the mobile tongue. BT located tumors were more frequent than previously published. Additional frequency studies will define outcomes in age cohorts with a consensus cutoff for young and elderly populations. More population-based studies should be performed in Latin American regions to acquire accurate data on SCC incidence in elder subpopulations and to identify precisely the etiological factors in these patients.

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Section: Agesupporting

confidence: 82%

Section: Tnm Classificationmentioning

confidence: 92%

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Squamous cell carcinoma of the tongue in patients older than 45 years

et al. 2018

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“…Recent studies have reported that such cases had a high rate of lymph node metastasis, recurrence, and cancer-related mortality [2,3]. In our previous study covering all stages (I-IV) of OTSCC, stage II Table 1 T staging criteria for small OTSCC (≤ 4 cm in diameter) with clinically negative neck in the AJCC 7th, the AJCC 8th (which incorporated depth of invasion, DOI (DOI is the measurement of depth of invasion and not tumor thickness)), and our proposal using a lower cutoff point for DOI patients had a poor survival, which was almost similar to stage III patients [14]. This indicates understaging in some stage II cases according to the AJCC 7th [5].…”

Section: Discussionmentioning

confidence: 67%

Small oral tongue cancers (≤ 4 cm in diameter) with clinically negative neck: from the 7th to the 8th edition of the American Joint Committee on Cancer

et al. 2018

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One of the main changes in the 8th edition of the American Joint Committee on Cancer (AJCC) for staging of oral cancer is the inclusion of depth of invasion (DOI) in the T category. However, cancers in different oral subsites have variable behavior, with oral tongue squamous cell carcinoma (OTSCC) being the most aggressive one even at early stage. Thus, it is necessary to evaluate the performance of this new T category in homogenous cohort of early OTSCC. Therefore, we analyzed a large cohort of patients with a small (≤ 4 cm) OTSCC to demonstrate the differences in T stage between the AJCC 7th and 8th editions. A total of 311 early-stage cases (AJCC 7th) of OTSCC were analyzed. We used 5 mm and 10 mm DOI for upstaging from T1 to T2 and from T2 to T3 respectively, as in the AJCC 8th. We further reclassified the cases according to our own proposal suggesting 2 mm to upstage to T2 and 4 mm to upstage to T3. According to AJCC 7th, there were no significant differences in the survival analysis. When we applied the 8th edition, many cases were upstaged to T3 and thus associated with worse disease-specific survival (HR 2.37, 95% CI 1.12-4.99) and disease-free survival (HR 2.12, 95% CI 1.09-4.08). Based on our proposal, T3 cases were associated with even worse disease-specific survival (HR 4.19, 95% CI 2.27-7.74). The 8th edition provides better survival prediction for OTSCC than the 7th and can be further optimized by lowering the DOI cutoffs.

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“…Oral tongue squamous cell carcinoma (OTSCC) is globally the most frequent type of oral cancer in terms of epidemiology [1]. It is a highly aggressive cancer associated with a low rate of local tumour control, and, despite advances in diagnostics and therapeutics, the 5-year survival rate remains low, around 60% [2].…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase 9 inhibits the motility of highly aggressive HSC-3 oral squamous cell carcinoma cells

Väyrynen

Åström

Nyberg

et al. 2019

Experimental Cell Research

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Pro-tumorigenic activities of matrix metalloproteinase (MMP) 9 have been linked to many cancers, but recently the tumour-suppressing role of MMP9 has also been elucidated. The multifaceted evidence on this subject prompted us to examine the role of MMP9 in the behaviour of oral tongue squamous cell carcinoma (OTSCC) cells. We used gelatinase-specific inhibitor, CTT2, and short hairpin (sh) RNA gene silencing to study the effects of MMP9 on proliferation, motility and invasion of an aggressive OTSCC cell line, HSC-3. We found that the migration and invasion of HSC-3 cells were increased by CTT2 and shRNA silencing of MMP9. Proliferation, in turn, was decreased by MMP9 inhibition. Furthermore, arresten-overexpressing HSC-3 cells expressed increased levels of MMP9, but exhibited decreased motility compared with controls. Interestingly, these cells restored their migratory capabilities by CTT2 inhibition of MMP9. Hence, although higher MMP9 expression could give rise to an increased tumour growth in vivo due to increased proliferation, in some circumstances, it may participate in yet unidentified molecular mechanisms that reduce the cell movement in OTSCC.

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Improved outcomes with oral tongue squamous cell carcinoma in Finland

Cited by 41 publications

References 28 publications

Squamous cell carcinoma of the tongue in patients older than 45 years

Squamous cell carcinoma of the tongue in patients older than 45 years

Small oral tongue cancers (≤ 4 cm in diameter) with clinically negative neck: from the 7th to the 8th edition of the American Joint Committee on Cancer

Matrix metalloproteinase 9 inhibits the motility of highly aggressive HSC-3 oral squamous cell carcinoma cells

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