Improved overall survival and mortality in head and neck cancer with adjuvant concurrent chemoradiotherapy in national databases

Abstract

The literature shows mortality benefit of adjuvant CRT in patients with advanced head and neck cancer, reflected in SEER and NCDB.

Dental demineralization and caries in patients with head and neck cancer

“…Increased use of chemoradiation for patients with locally advanced HNC has improved local disease control and overall survival [1]. Unfortunately, chemoradiation is associated with increased acute and late effects that result in substantial symptom burden and decrements in quality of life (QOL) [2][3][4][5].…”

Top 10 research priorities in head and neck cancer: Results of an Alberta priority setting partnership of patients, caregivers, family members, and clinicians

“…Head and neck cancer associated with tobacco and alcohol usage is on the decline in developed Western countries, whereas there has been a significant increase in the incidence of oropharyngeal cancer associated with human papillomavirus (HPV) infection . Although the 5‐year survival rates for patients with head and neck cancer vary widely by tumor type and site, in the past 2 decades there have been significant improvements in oropharyngeal cancer survival rates and some improvement in survival in other head and neck cancer sites …”

Survival outcomes for postoperative chemoradiation in intermediate‐risk oral tongue cancers

“…By contrast, 2 randomized trials demonstrated that chemoradiotherapy (CRT) for the high‐risk pathological features of positive surgical margins and/or extracapsular extension improved disease‐free survival and/or overall survival (OS) . Furthermore, a population‐based analysis from the National Cancer Database (NCDB) indicated that postoperative CRT improved the OS in patients with these high‐risk pathological features …”