This paper intends to provide design selections of hybrid powertrain architectures in 48 V mild hybrid electric vehicles. Based on the location of the electric machine in the driveline, the hybrid powertrain architectures can be categorized into five groups, P0, P1, P2, P3, and P4. This paper uses simulation software to investigate the fuel economy improvements and emission reduction of 48 V mild hybrid electric vehicles with P0, P1, and P2 architectures. A baseline conventional and a 12 V start/stop vehicle models based on the production vehicle are built for comparison. The 48 V battery pack model is based on experimental data including open-circuit voltage and internal resistance of a 20 Ah lithium polymer battery cell. Four standard driving cycles are used to assess the fuel economy and emissions of the vehicle models. With features of engine idle elimination, electric power assist, and regenerative braking, the 48 V P0 and P1 respectively gains average 13.5% and 15.5% simulated fuel economy compared to baseline vehicle. The 48 V P2 enables feature of electric launch/driving and improves the fuel economy by average 18.5% better than baseline vehicle. The 48 V mild hybrid system seems to be one of the promising techniques to meet future fuel economy standards and emission regulations.