Improved periodontal health and cardiovascular risk

Rose-Hill, S.; Ford, Pauline; Leishman, Shaneen; L., H.; Palmer, Jennifer L.; Heng, Nicholas C. K.; West, Malcolm; Seymour, G. J.; Cullinan, M. P.

doi:10.1111/j.1834-7819.2011.01363.x

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…No evidence of a similar effect of periodontal therapy on sICAM-1 and sVCAM-1 was found (Lalla et al 2007, Pischon et al 2007, Marcaccini et al 2009a. We found only one trial reporting a reduction of sICAM-1 after periodontal therapy in patients with low CVD risk (Rose-Hill et al 2011).…”

Section: Circulating Cell Adhesion Moleculesmentioning

confidence: 74%

Evidence that periodontal treatment improves biomarkers and CVD outcomes

D’Aiuto

Orlandi

Gunsolley

2013

Journal of Periodontology

128

137

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Evidence that periodontal treatment improves biomarkers and CVD outcomes D'Aiuto F, Orlandi M, Gunsolley JC. Evidence that periodontal treatment improves biomarkers and CVD outcomes. AbstractAim: The aim of this review was to critically appraise the evidence on the impact of periodontal treatment of cardiovascular diseases (CVDs) biomarkers and outcomes. Methods: A systematic search was performed in Cinhal, Cochrane, Embase and Medline for relevant articles up to July 2012. Duplicate screening and reference hand searching were performed. Data were then summarized and evidence graded in tables. Results: The search resulted in: (a) no evidence on the effects of periodontal therapy on subclinical atherosclerosis, serum levels of CD40 ligand, serum amyloid A and monocyte chemoattractant protein-1, (b) limited evidence on the effects of periodontal therapy on arterial blood pressure, leucocyte counts, fibrinogen, tissue necrosis factor-a, sE-selectin, von Willebrand factors, d-dimers, matrix metalloproteinases, oxidative stress and CVD events, and (c) moderate evidence suggesting a negligible effect of periodontal therapy in reducing interleukin-6 and lipids levels, whilst a positive effect in reducing serum C-reactive protein levels and improving endothelial function. Conclusions: Periodontal therapy triggers a short-term inflammatory response followed by (a) a progressive and consistent reduction of systemic inflammation and (b) an improvement in endothelial function. There is however limited evidence that these acute and chronic changes will either increase or reduce CVD burden of individuals suffering from periodontitis in the long term.

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Section: Circulating Cell Adhesion Moleculesmentioning

confidence: 74%

Evidence that periodontal treatment improves biomarkers and CVD outcomes

D’Aiuto

Orlandi

Gunsolley

2013

Journal of Periodontology

128

137

View full text Add to dashboard Cite

show abstract

“…We found only one trial reporting a reduction of sICAM‐1 after periodontal therapy in patients with low CVD risk (Rose‐Hill et al. ).…”

Section: Resultsmentioning

confidence: 99%

Evidence that periodontal treatment improves biomarkers and CVD outcomes

D’Aiuto

Orlandi

Gunsolley

2013

J Clinic Periodontology

177

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Aim: The aim of this review was to critically appraise the evidence on the impact of periodontal treatment of cardiovascular diseases (CVDs) biomarkers and outcomes. Methods: A systematic search was performed in Cinhal, Cochrane, Embase and Medline for relevant articles up to July 2012. Duplicate screening and reference hand searching were performed. Data were then summarized and evidence graded in tables. Results: The search resulted in: (a) no evidence on the effects of periodontal therapy on subclinical atherosclerosis, serum levels of CD40 ligand, serum amyloid A and monocyte chemoattractant protein-1, (b) limited evidence on the effects of periodontal therapy on arterial blood pressure, leucocyte counts, fibrinogen, tissue necrosis factor-a, sE-selectin, von Willebrand factors, d-dimers, matrix metalloproteinases, oxidative stress and CVD events, and (c) moderate evidence suggesting a negligible effect of periodontal therapy in reducing interleukin-6 and lipids levels, whilst a positive effect in reducing serum C-reactive protein levels and improving endothelial function. Conclusions: Periodontal therapy triggers a short-term inflammatory response followed by (a) a progressive and consistent reduction of systemic inflammation and (b) an improvement in endothelial function. There is however limited evidence that these acute and chronic changes will either increase or reduce CVD burden of individuals suffering from periodontitis in the long term.

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“…Overall, the effect of periodontal treatment on these biomarkers is variable and inconclusive. For example, one study (118) showed a decrease in the serum levels of soluble intercellular adhesion molecule‐1 with improvement in periodontal health, while another (110) showed no change following periodontal therapy. These results again emphasize the need for more studies, with larger sample sizes, over a longer term.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Periodontal disease and systemic illness: will the evidence ever be enough?

Cullinan¹,

Seymour²

2013

Periodontology 2000

200

154

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The concept of focal infection or systemic disease arising from infection of the teeth was generally accepted until the mid-20th century when it was dismissed because of lack of evidence. Subsequently, a largely silo approach was taken by the dental and medical professions. Over the past 20 years, however, a plethora of epidemiological, mechanistic and treatment studies have highlighted that this silo approach to oral and systemic diseases can no longer be sustained. While a number of systemic diseases have been linked to oral diseases, the weight of evidence from numerous studies conducted over this period, together with several systematic reviews and meta-analyses, supports an association between periodontitis and cardiovascular disease, and between periodontitis and diabetes. The association has also been supported by a number of biologically plausible mechanisms, including direct infection, systemic inflammation and molecular mimicry. Treatment studies have shown that periodontal treatment may have a small, but significant, systemic effect both on endothelial function and on glycemic control. Despite this, however, there is no direct evidence that periodontal treatment affects either cardiovascular or diabetic events. Nevertheless, over the past 20 years we have learnt that the mouth is an integral part of the body and that the medical and dental professions need to work more closely together in the provision of overall health care for all patients.

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Improved periodontal health and cardiovascular risk

Cited by 5 publications

References 31 publications

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Periodontal disease and systemic illness: will the evidence ever be enough?

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