Improved Peripheral Nerve Regeneration Using Acellular Nerve Allografts Loaded with Platelet-Rich Plasma

Zheng, Canbin; Zhu, Qian; Liu, Xiaolin; Huang, Xijun; He, Chao; Jiang, Li; Quan, Daping

doi:10.1089/ten.tea.2013.0729

Cited by 67 publications

(56 citation statements)

References 44 publications

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“…Similarly, combining PRP with an autologous sensory nerve results in enhanced axon regeneration across short (i.e., 1 cm long) nerve gaps [223]. Further, it has been shown that the application of PRP to a nerve anastomosis site enhances the extent of axon regeneration [29].…”

Section: Animal: Improvementmentioning

confidence: 99%

“…PRP within acellular nerve grafts induce axon regeneration that is significantly greater than through the nerve graft alone, but it is good only for nerve gaps up to 1.5 cm in length [223]. Creation of a conduit of PRP around the region of peripheral nerve anastomosis with sutures induces more axon regeneration than without the PRP membrane [29].…”

Section: Clinical: Improvementmentioning

confidence: 99%

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Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Kuffler

2015

Mol Neurobiol

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Platelet-rich plasma (PRP) has been tested in vitro, in animal models, and clinically for its efficacy in enhancing the rate of wound healing, reducing pain associated with injuries, and promoting axon regeneration. Although extensive data indicate that PRP-released factors induce these effects, the claims are often weakened because many studies were not rigorous or controlled, the data were limited, and other studies yielded contrary results. Critical to assessing whether PRP is effective are the large number of variables in these studies, including the method of PRP preparation, which influences the composition of PRP; type of application; type of wounds; target tissues; and diverse animal models and clinical studies. All these variables raise the question of whether one can anticipate consistent influences and raise the possibility that most of the results are correct under the circumstances where PRP was tested. This review examines evidence on the potential influences of PRP and whether PRP-released factors could induce the reported influences and concludes that the preponderance of evidence suggests that PRP has the capacity to induce all the claimed influences, although this position cannot be definitively argued. Well-defined and rigorously controlled studies of the potential influences of PRP are required in which PRP is isolated and applied using consistent techniques, protocols, and models. Finally, it is concluded that, because of the purported benefits of PRP administration and the lack of adverse events, further animal and clinical studies should be performed to explore the potential influences of PRP.

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Section: Animal: Improvementmentioning

confidence: 99%

Section: Clinical: Improvementmentioning

confidence: 99%

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Kuffler

2015

Mol Neurobiol

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“…PRP has been used to study the effect of stimulating neural regeneration of the rat facial nerve, 64 rat sciatic nerve, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 rat cavernous nerve, 75, 76 guinea pig facial nerve, 77 rabbit sciatic nerve, 78 dog anterior cruciate ligament 79 and rat spinal cord. 80 These studies presented positive results regarding functional nerve recovery, 64, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 80 regeneration of axons, 64, 65, 70, 71, 72, 75, 76 g-ratio (an index of optimal axonal myelination), 67 thickness of the myelin sheath, 66, 70, 77, 78 nerve conduction velocity, 78 revascularization and reinnervation, 79 and axon diameter, 69, 70, 80 with observation periods ranging from 2 to 12 weeks postoperatively.…”

Section: Prp Treatment: Preparation and Biological Characteristicsmentioning

confidence: 99%

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

et al. 2017

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Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma (PRP) therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field. Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and (pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed.

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“…Kim et al found that PRP injection significantly improved the surviving area of flaps in rabbits through angiogenic and arteriogenic effects [30]. In a rat model, Zheng et al showed that acellular nerve allografts loaded with P-PRP as tissue-engineered scaffolds can enhance nerve regeneration and functional recovery after the repair of large nerve gaps nearly as well as autografts [31]. Tajima et al showed that transplantation of the adipose-derived stem cell and PRP mixture had dramatic effects on bone regeneration overtime [11].…”

Section: Animal Studiesmentioning

confidence: 99%

Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

Sclafani

Azzi

2015

Aesth Plast Surg

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In facial plastic surgery, the potential for direct delivery of growth factors from platelet preparations has been of particular interest for use in facial rejuvenation, recovery after facial surgery, and wound healing. A literature search was conducted through PubMed for the terms PRP, PRFM, platelet-rich plasma, platelet-rich fibrin matrix, platelet preparations, platelet therapy, growth factors, platelet facial, platelet facial rejuvenation, platelet wound healing, platelet plastic surgery. Articles pertaining to the use of platelet preparations in facial surgery and wound healing in plastic surgery after 2001 were included. Thirteen in vitro studies showed use of platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM) had a significant effect on cellular activity. Twenty-four out of 28 animal studies exhibited favorable results with use of a platelet preparation, including five of six studies that showed enhanced fat graft survival with addition of a platelet preparation. Twenty-three case series and clinical trials were identified, only two of which showed no differences. Twenty-one reported favorable results with use of various platelet preparations. A total of 47 studies used PRP, four studies evaluated Leukocyte-rich PRP, and fourteen studies used PRFM. The vast majority of studies examined show a significant and measurable effect on cellular changes, wound healing, and facial esthetic outcomes with use of platelet preparations, both topical and injectable. One must also consider possible publication bias against null results that may have had an influence on the data that were available for review. However, the preponderance of studies suggests that platelet preparations might represent an as-of-yet untapped adjunct in facial plastic surgery.

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Improved Peripheral Nerve Regeneration Using Acellular Nerve Allografts Loaded with Platelet-Rich Plasma

Cited by 67 publications

References 44 publications

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

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