Improved photostability indicating ion-pair chromatography method for pergolide analysis in tablets and in the presence of cyclodextrins

Kotzagiorgis, Evangelos Ch.; Michaleas, Sotiris; Antoniadou-Vyza, Ekaterini

doi:10.1016/j.jpba.2006.11.019

Cited by 5 publications

References 11 publications

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Alkaloids, Pharmaceutical Analysis of

Gilpin

2000

Encyclopedia of Analytical Chemistry

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As a major class of compounds, alkaloids are naturally occurring bases with a wide range of structures, chemical, and physical properties, and pharmacological activities. The use of alkaloids as medical agents in the form of crude plant powders and extracts predates the modern pharmaceutical industry by almost four millennia and in some instances prior to modern science. Mass poisonings have resulted from their inadvertent usage and was prevalent in Europe during the Middle Ages as the result of the general populace eating bread contaminated with Claviceps purpurea . The C. purpurea fungus produces an ergot alkaloid that first affects the central nervous system causing hallucinogenic effects and later death if enough is ingested. Ergot poisoning in the Middles Ages is perhaps best known for its effect on the painters “of‐the‐day” and their impressionistic styles and use of vivid colors.

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Alkaloids, Pharmaceutical Analysis of

Gilpin

2000

Encyclopedia of Analytical Chemistry

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Photostabilization of oxolinic acid in hydroxypropyl-β-cyclodextrins; implications for the effect of molecular self-assembly phenomena

Orfanou

Michaleas

Benaki

et al. 2009

J Incl Phenom Macrocycl Chem

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Effects of compounding and storage conditions on stability of pergolide mesylate

Davis

Kirk²,

Davidson³

et al. 2009

javma

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Results indicated that pergolide mesylate was unstable after compounding in an aqueous vehicle and that storage conditions had an effect on stability of the compounded formulation. Compounded pergolide formulations in aqueous vehicles should be stored in a dark container, protected from light, and refrigerated and should not be used >30 days after produced. Formulations that have undergone a color change should be considered unstable and discarded.

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Improved photostability indicating ion-pair chromatography method for pergolide analysis in tablets and in the presence of cyclodextrins

Cited by 5 publications

References 11 publications

Alkaloids, Pharmaceutical Analysis of

Alkaloids, Pharmaceutical Analysis of

Photostabilization of oxolinic acid in hydroxypropyl-β-cyclodextrins; implications for the effect of molecular self-assembly phenomena

Effects of compounding and storage conditions on stability of pergolide mesylate

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