Improved Production of Plant Isoquinoline Alkaloids by Metabolic Engineering

Naturally occurring plant isoquinoline N-oxide alkaloids: Their pharmacological and SAR activities

“…Isoquinoline N-oxide alkaloids ( Fig. 1) are structurally related to their corresponding alkaloids, and these alkaloids showed high pharmacological active properties (Sato 2013;Nakagawa et al 2013;Majak et al 2003). Heterocyclic N-oxides and N-imides, alkaloid N-oxides, and their synthesis of oxygen-containing heterocycles by intramolecular oxypalladation has recently been reviewed (El Antri et al 2004;Taylor 1960).…”