Improved protein detection on an AC electrokinetic quartz crystal microbalance (EKQCM)

Hart, R. W.; Ergezen, E.; Lec, R.M.; Noh, Hyunwoo

doi:10.1016/j.bios.2010.12.038

Cited by 24 publications

(17 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, ACEO and ETF have also been discovered [14][15][16] and some of their applications have been explored [17][18][19]. Strictly speaking, these are electrohydrodynamic phenomena and their major application is mixing, which is a challenging task in microchannel laminar flows and miniature biosensor platforms [20,21].…”

Section: Introductionmentioning

confidence: 98%

Dielectrophoretic particle–particle interaction under AC electrohydrodynamic flow conditions

Lee

Papazoglou

et al. 2011

Electrophoresis

View full text Add to dashboard Cite

We used the Maxwell stress tensor method to understand dielectrophoretic particle-particle interactions and applied the results to the interpretation of particle behaviors under alternating current (AC) electrohydrodynamic conditions such as AC electroosmosis (ACEO) and electrothermal flow (ETF). Distinct particle behaviors were observed under ACEO and ETF. Diverse particle-particle interactions observed in experiments such as particle clustering, particles keeping a certain distance from each other, chain and disc formation and their rotation, are explained based on the numerical simulation data. The improved understanding of particle behaviors in AC electrohydrodynamic flows presented here will enable researchers to design better particle manipulation strategies for lab-on-a-chip applications.

show abstract

Section: Introductionmentioning

confidence: 98%

Dielectrophoretic particle–particle interaction under AC electrohydrodynamic flow conditions

Lee

Papazoglou

et al. 2011

Electrophoresis

View full text Add to dashboard Cite

show abstract

“…In the last few yeats thete has been significant wotk cattied out towatds the imptovement of the sttuctutal and electtical ptopetties of ZnO and A1N thin films fot theit use as the active material inthese devices [18][19][20][21][22][23][24] howevetthe Q_ factots ofthese tesonatots ate still lowet than those ofQCMs [25,26], limiting theit sensitivity.…”

Section: Introductionmentioning

confidence: 99%

AlN-based BAW resonators with CNT electrodes for gravimetric biosensing

Garcia‐Gancedo

Zhu

Iborra

et al. 2011

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

ARTICLE INFO ABSTRACTSolidly mounted resonators (SMRs) with a top carbón nanotubes (CNTs) surface coating that doubles as an electrode and as a sensing layer have been fabricated. The influence of the CNTs on the frequency response of the resonators was studied by direct comparison to identical devices with a top metallic electrode. It was found that the CNTs introduced significantly less mass load on the resonators and these devices exhibited a greater quality factor, Q.(>2000, compared to ~1000 for devices with metal electrodes), which increases the gravimetric sensitivity of the devices by allowing the tracking of smaller ~ " frequency shifts. Protein solutions with different concentrations were loaded on the top of the resonators Keywords' Biosensor anc ' me ' r res P onses to mass-load from physically adsorbed coatings were investigated. Results show Carbón nanotube (CNT) tnat resonators using CNTs as the top electrode exhibited a higher frequency change for a given load Aluminum nitride (A1N) (~0.25 MHz cm 2 ng _1 ) compared to that of a metal thin film electrode (~0.14 MHz cm 2 ng _1 ), due to the Bulk acoustic wave resonator (BAW) lower mass of the CNT electrodes and their higher active surface área compared to that of a thin film Gravimetric biosensor metal electrode. It is therefore concluded that the use of CNT electrodes on resonators for their use as gravimetric biosensors is a significant improvement over metallic electrodes that are normally employed.

show abstract

“…[1][2][3] Moreover, a variety of these biochemical processes, such as surface-enhanced Raman scattering (SERS) 4,5 and flow cytometry 6 , demand for parallel or serial analyses with ascending/descending analyte concentrations to evaluate the optimal condition. [1][2][3] Moreover, a variety of these biochemical processes, such as surface-enhanced Raman scattering (SERS) 4,5 and flow cytometry 6 , demand for parallel or serial analyses with ascending/descending analyte concentrations to evaluate the optimal condition.…”

Section: Introductionmentioning

confidence: 99%

Scaled particle focusing in a microfluidic device with asymmetric electrodes utilizing induced-charge electroosmosis

Ren

Liu

et al. 2016

Lab Chip

View full text Add to dashboard Cite

We propose a novel continuous-flow microfluidic particle concentrator with a specified focusing-particle number ratio (FR) at different channel outlets using induced-charge electroosmosis (ICEO). The particle-focusing region contains two floating electrodes of asymmetric widths L2 and L1 in the gap between a driving electrode pair, all of which are fabricated in parallel in the main channel. Applying an AC voltage over the driving electrodes, an ICEO flow with two vortexes can be induced over each of the two floating electrodes, and the actuation range of the ICEO vortex is proportional to the respective electrode size. We establish a preliminary physical model for the value of FR: at a moderate voltage and frequency range, FR approaches L2/L1 due to the scaled ICEO actuation range; by further modifying the voltage or frequency, FR is freely adjustable because of the variation in ICEO velocity. Furthermore, by connecting multiple focusing regions in series, i.e., high FR = (L2/L1)(n) can be conveniently generated in an n-stage flow focusing device. Our results provide a promising method for yielding transverse concentration gradients of particles useful in pre-processing before analysis.

show abstract

Improved protein detection on an AC electrokinetic quartz crystal microbalance (EKQCM)

Cited by 24 publications

References 34 publications

Dielectrophoretic particle–particle interaction under AC electrohydrodynamic flow conditions

Dielectrophoretic particle–particle interaction under AC electrohydrodynamic flow conditions

AlN-based BAW resonators with CNT electrodes for gravimetric biosensing

Scaled particle focusing in a microfluidic device with asymmetric electrodes utilizing induced-charge electroosmosis

Contact Info

Product

Resources

About