Improved pulmonary function test (PFT) after 1 one year of Sublingual Immunotherapy (SLIT) in unison with pharmacotherapy in mild allergic asthmatics

Beigh, Afaq H.; Rasool, Roohi; Kawoosa, Fizalah; manzoor, Sharika; Rashid, Rabiya; Andrabi, Khurshid Iqbal; Shah, Zafar A.; Qureshi, Taha

doi:10.1016/j.imlet.2020.12.004

Cited by 6 publications

(1 citation statement)

References 26 publications

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“…The effect of sublingual immunotherapy on asthma is still being evaluated, A recent study supports SLIT as an effective treatment for Immunomodulation in mild allergic asthmatics besides it gives us significant information regarding the safety and efficacy of SLIT in such patients. (Beigh et al, 2021).…”

Section: Table (1): Assessing Asthma Severity (Nhlbi Guidelines 2020) Nhlbi: National Heart Lung and Blood Institutementioning

confidence: 99%

Recent trends in management of bronchial asthma

goda

Sileem

El-Nahas

et al. 2021

Zagazig Journal of Pharmaceutical Sciences

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Bronchial Asthma is the most common chronic inflammatory disease of lungs. The prevalence of asthma is increasing worldwide, and the disease possesses a substantial global health and economic burden. Asthma involves both the large and the small-conducting airways, and is characterized by a combination of inflammation and structural remodeling. Disease progression occurs in the context of a developmental background in which the postnatal acquisition of asthma is strongly linked with allergic sensitization. Most asthma cases follow a variable course, involving viral-induced wheezing and allergen sensitization, that is associated with various underlying mechanisms (or endotypes) that can differ between individuals. Each set of endotypes, in turn, produces specific asthma characteristics that evolve across the life course of the patient. Strong genetic and environmental drivers of asthma interconnect through novel epigenetic mechanisms that operate prenatally and throughout childhood. Asthma can spontaneously remit or begin de novo in adulthood, and the factors that lead to the emergence and regression of asthma, irrespective of age, are poorly understood. Nonetheless, there is mounting evidence that supports a primary role for structural changes in the airways with asthma acquisition, on which altered innate immune mechanisms and microbiota interactions are superimposed. On the basis of the identification of new causative pathways, the sub-phenotyping of asthma across the life course of patients is paving the way for more-personalized and precise pathway-specific approaches for the prevention and treatment of asthma, creating the real possibility of total prevention and cure for this chronic inflammatory disease.

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Section: Table (1): Assessing Asthma Severity (Nhlbi Guidelines 2020) Nhlbi: National Heart Lung and Blood Institutementioning

confidence: 99%

Recent trends in management of bronchial asthma

goda

Sileem

El-Nahas

et al. 2021

Zagazig Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

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Ameliorating Atopy by Compensating Micronutritional Deficiencies in Immune Cells: A Double-Blind Placebo-Controlled Pilot Study

Bartosik¹,

Jensen²,

Afify³

et al. 2022

The Journal of Allergy and Clinical Immunology: In Practice

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Immune mechanisms induced by sublingual immunotherapy in allergic respiratory diseases

Gazi

Bahceciler

2022

Clinical and Experimental Immunology

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Allergic respiratory diseases (ARDs) are still a major burden on global public health. Sublingual immunotherapy (SLIT) is a mode of allergen immunotherapy (AIT) which involves administration of the allergen under the tongue, and benefits from tolerogenic properties of the oral mucosa. Studies revealed reduced levels of eosinophilia and eosinophil-dominated inflammation in airways of both animals and humans after SLIT. SLIT was also suggested to lower basophil responsiveness and innate lymphoid cell-2 function in blood samples collected from ARD patients. Moreover, apart from shifting pathogenic type 2 (TH2) to a type 1 (TH1) and protective regulatory (Treg) polarization of helper T-cell immune response, antibody isotype switch from IgE to IgG1, IgG2, IgG4 and IgA was also reported in ARD patients receiving SLIT. Today, the literature on SLIT-mediated activities is still scarce and more studies are required to further enlighten the mechanisms utilized by SLIT for the induction of tolerance. The aim of this review is to summarize the current knowledge about the immune-regulatory mechanisms induced by SLIT against ARDs.

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Improved pulmonary function test (PFT) after 1 one year of Sublingual Immunotherapy (SLIT) in unison with pharmacotherapy in mild allergic asthmatics

Cited by 6 publications

References 26 publications

Recent trends in management of bronchial asthma

Recent trends in management of bronchial asthma

Ameliorating Atopy by Compensating Micronutritional Deficiencies in Immune Cells: A Double-Blind Placebo-Controlled Pilot Study

Immune mechanisms induced by sublingual immunotherapy in allergic respiratory diseases

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