Improved Reflux Monitoring in the Acute Gastroesophageal Reflux Porcine Model Using Esophageal Multichannel Intraluminal Impedance Measurement

Abstract

MII improves the detection of reflux in the acute reflux porcine model. The finding that after sole mobilization of the esophagus the intragastric pressure needed to provoke reflux was increased although the finding that the pressure of the lower esophageal sphincter was decreased needs further investigation.

Newborn Lamb as a New Model for Studying Gastroesophageal Reflux

“…An extensive review of the literature showed that there are only a few animal models for studying GER (rats, dogs, cats, pigs) [8,18]. Most of these models were specifically designed to characterize GER in non-physiological conditions and during short-term measurements (mostly < 1 hour) [8,19]. In addition, there are no animal models of GER in newborns.…”

“…An extensive review of the literature reveals that there are only a few published animal models for studying GER (rats, dogs, cats, pigs) mostly in nonphysiological conditions and during shortterm measurements (mostly < 1 hour) (10)(11)(12)). An exception is the adult rat, which has been used for studying the consequences of chronic reflux related lung aspirations (13).…”

Laparoscopic Mesh-augmented Hiatoplasty With Cardiophrenicopexy Versus Laparoscopic Nissen Fundoplication for the Treatment of Gastroesophageal Reflux Disease

“…This was, based on the hypothesis that lengthening of the intra-abdominal part of the esophagus improves lower esophageal sphincter (LES) function and, consequentially, resolves gastroesophageal reflux. 6,7 This hypothesis has been supported by experimental findings 8 and meticulous considerations on the physiology of the LES by Stelzner et al As a consequence of their research, they postulated a stretch closure mechanism of the LES, which improves after isometric distention of the spiral esophageal muscular fibers. [9][10][11] Initial results of cardiophrenicopexy procedures were promising as reflux control was achieved in up to 90% of patients.…”

Intravenous 64‐multi‐detector row CT‐cholangiography of porcine livers: a feasibility study with definition of the temporal window for optimal bile duct delineation

“…After endotracheal intubation, the animals were anesthetized with isoflurane and N 2 O [27]. No muscle relaxation was performed [28]. After surgical exposure, the right internal jugular vein was punctured and a 4F central venous catheter introduced.…”