Improved Renal Perfusion Prevents Disease Progression in Focal Segmental Glomerulosclerosis

Futrakul, Prasit; Futrakul, Narisa; Sitprija, Visith; Sensirivatana, Rajanee; Watana, Dhevy; Kingwatanakul, Pornchai

doi:10.1159/000188492

Cited by 5 publications

(2 citation statements)

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“…Deficits in blood perfusion (e.g., ischemia and hypoxia) are a cause of and/or complication associated with a number of disease states including tissue infarction, necrosis, wound healing, tissue grafting, and organ dysfunction. In addition to the more familiar examples of perfusion deficit such as stroke [175], MI [119], peripheral vascular disease [137], and diabetes [57,77], vascular insufficiencies are a significant component of renal disease [72], retinopathies [19,42,47], fibro‐proliferative disorders [46,86], chronic ischemia [14,63], hypertension [112,164], and others. Furthermore, vascular rarefaction of mature microcirculations, a consequence of microvascular instability, is thought to contribute to tissue hypo‐perfusion in diabetes, hypertension fibrotic disorders, pulmonary diseases, and others [63,81,112,202].…”

Section: Vascular Deficit and Repairmentioning

confidence: 99%

Microvascular Repair: Post‐Angiogenesis Vascular Dynamics

et al. 2012

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Vascular compromise and the accompanying perfusion deficits cause or complicate a large array of disease conditions and treatment failures. This has prompted the exploration of therapeutic strategies to repair or regenerate vasculatures thereby establishing more competent microcirculatory beds. Growing evidence indicates that an increase in vessel numbers within a tissue does not necessarily promote an increase in tissue perfusion. Effective regeneration of a microcirculation entails the integration of new stable microvessel segments into the network via neovascularization. Beginning with angiogenesis, neovascularization entails an integrated series of vascular activities leading to the formation of a new mature microcirculation and includes vascular guidance and inosculation, vessel maturation, pruning, arterio-venous specification, network patterning, structural adaptation, intussusception, and microvascular stabilization. While the generation of new vessel segments is necessary to expand a network, without the concomitant neovessel remodeling and adaptation processes intrinsic to microvascular network formation, these additional vessel segments give rise to a dysfunctional microcirculation. While many of the mechanisms regulating angiogenesis have been detailed, a thorough understanding of the mechanisms driving post-angiogenesis activities specific to neovascularization has yet to be fully realized, but is necessary in order to develop effective therapeutic strategies for repairing compromised microcirculations as a means to treat disease.

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Section: Vascular Deficit and Repairmentioning

confidence: 99%

Microvascular Repair: Post‐Angiogenesis Vascular Dynamics

et al. 2012

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“…Pertaining to this conceptual view, pre vention of disease progression could be accomplished by improving the renal per fusion with adequate therapy, including vasodilators [4,[17][18][19][20][21]. Following such a therapeutic approach, reductions of renal ar teriolar resistances and of the intraglomeru lar hydrostatic pressure were documented in conjunction with increments in renal plasma flow, glomerular filtration rate, ultrafiltra tion coefficient, as well as tubular function.…”

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confidence: 99%