NASA's carbon dioxide mission, Orbiting Carbon Observatory-2, began operating in September 2014. In this paper, we analyze four years (2015)(2016)(2017)(2018) of global (60 • S-60 • N) XCO 2 anomalies and their annual variations and seasonal patterns. We show that the anomaly patterns in the column-averaged CO 2 dry air mole fraction, XCO 2 , are robust and consistent from year-to-year. We evaluate the method by comparing the anomalies to fluxes from anthropogenic, biospheric, and biomass burning and to model-simulated local concentration enhancements. We find that, despite the simplicity of the method, the anomalies describe the spatio-temporal variability of XCO 2 (including anthropogenic emissions and seasonal variability related to vegetation and biomass burning) consistently with more complex model-based approaches. We see, for example, that positive anomalies correspond to fossil fuel combustion over the major industrial areas (e.g., China, eastern USA, central Europe, India, and the Highveld region in South Africa), shown as large positive XCO 2 enhancements in the model simulations. We also find corresponding positive anomalies and fluxes over biomass burning areas during different fire seasons. On the other hand, the largest negative anomalies correspond to the growing season in the northern middle latitudes, characterized by negative XCO 2 enhancements from simulations and high solar-induced chlorophyll fluorescence (SIF) values (indicating the occurrence of photosynthesis). The largest discrepancies between the anomaly patterns and the model-based results are observed in the tropical regions, where OCO-2 shows persistent positive anomalies over every season of every year included in this study. Finally, we demonstrate how XCO 2 anomalies enable the detection of anthropogenic signatures for several local scale case studies, both in the Northern and Southern Hemisphere. In particular, we analyze the XCO 2 anomalies collocated with the recent TROPOspheric Monitoring Instrument NO 2 observations (used as indicator of anthropogenic fossil fuel combustion) over the Highveld region in South Africa. The results highlight the capability of satellite-based observations to monitor natural and man-made CO 2 signatures on global scale. all over the world and show levels that are about 100 ppm higher than they were in 1958, when they were about 315 ppm. However, the measurement networks are still denser in the Western world.One of the most important applications of CO 2 measurements is to infer the surface CO 2 fluxes, i.e., sources and sinks (or emissions into and removal from the atmosphere). A variety of methods are commonly used to derive CO 2 fluxes from spatially resolved estimates of column-averaged CO 2 dry air mole fraction, XCO 2 . These methods can be broadly classified as analytic mass balance, plume dispersion, or atmospheric inversion methods. All three approaches predict or optimize surface fluxes needed to reproduce the observed XCO 2 distribution in the presence of the time-varying wind field. Groun...