Improved skin permeability and whitening effect of catechin-loaded transfersomes through topical delivery

Hsieh, Wan-Chu; Fang, Chih-Wun; Suhail, Muhammad; Vu, Quoc Lam; Chuang, Chih-Hung; Wu, Pao‐Chu

doi:10.1016/j.ijpharm.2021.121030

Cited by 17 publications

(6 citation statements)

References 29 publications

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“…Likewise, the irritation index for Al and the prepared nanogels scored 0.02 and 0.01, respectively. Hsieh and co-workers demonstrated the same results as our investigation, which supports further our findings . Finally, we can demonstrate that the prepared nanogel network had no adverse effects and can be used as a promising drug delivery system.…”

Section: Resultssupporting

confidence: 91%

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Synthesis and Evaluation of Alginate-Based Nanogels as Sustained Drug Carriers for Caffeine

et al. 2023

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The objective of this study is to design a polymeric network of nanogels for sustained release of caffeine. Therefore, alginate-based nanogels were fabricated by a free-radical polymerization technique for the sustained delivery of caffeine. Polymer alginate was crosslinked with monomer 2-acrylamido-2-methylpropanesulfonic acid by crosslinker N′,N′-methylene bisacrylamide. The prepared nanogels were subjected to sol–gel fraction, polymer volume fraction, swelling, drug loading, and drug release studies. A high gel fraction was seen with the increasing feed ratio of polymer, monomer, and crosslinker. Greater swelling and drug release were observed at pH 4.6 and 7.4 as compared to pH 1.2 due to the deprotonation and protonation of functional groups of alginate and 2-acrylamido-2-methylpropanesulfonic acid. An increase was observed in swelling, loading, and release of the drug with the incorporation of a high feed ratio of polymer and monomer, while a reduction was seen with the increase in crosslinker feed ratio. Similarly, an HET-CAM test was used to evaluate the safety of the prepared nanogels, which showed that the prepared nanogels have no toxic effect on the chorioallantoic membrane of fertilized chicken eggs. Similarly, different characterizations techniques such as FTIR, DSC, SEM, and particle size analysis were carried out to determine the development, thermal stability, surface morphology, and particle size of the synthesized nanogels, respectively. Thus, we can conclude that the prepared nanogels can be used as a suitable agent for the sustained release of caffeine.

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Section: Resultssupporting

confidence: 91%

“…Hsieh and co-workers demonstrated the same results as our investigation, which supports further our findings. 77 Finally, we can demonstrate that the prepared nanogel network had no adverse effects and can be used as a promising drug delivery system. (5) Blanchard, J.; Sawers, S. J.…”

Section: Het-cam Testmentioning

confidence: 89%

Synthesis and Evaluation of Alginate-Based Nanogels as Sustained Drug Carriers for Caffeine

et al. 2023

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“…As represented in Table 3 , the PDI value for all ITZ-TFS formulations was less than 0.5, which indicates the homogeneity of size distribution [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Optimization of Itraconazole Transferosomes-Loaded HPMC Hydrogel for Enhancing Its Antifungal Activity: 2^3 Full Factorial Design

et al. 2023

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Itraconazole (ITZ) is a triazole antifungal agent characterized by broad-spectrum activity against fungal infections. The main drawback of ITZ, when applied topically, is the low skin permeability due to the stratum corneum, the outermost layer of the skin, which represents the main barrier for drug penetration. Therefore, this study aimed to prepare itraconazole as transferosomes (ITZ-TFS) to overcome the barrier function of the skin. ITZ-TFSs were prepared by thin lipid film hydration technique using different surfactants, sodium lauryl sulfate (SLS) and sodium deoxycholate (SDC). The prepared ITZ-TFS were evaluated for entrapment efficiency (EE) %, particle size, polydispersity index (PDI), zeta potential, and in vitro drug release to obtain an optimized formula. The surface morphology of the optimized formula of ITZ-TFS was determined by transmission electron microscope (TEM). The optimized formulation was prepared in the form of gel using hydroxyl propyl methyl cellulose (HPMC) gel base. The prepared ITZ-TFS gel was evaluated for homogeneity, drug content, spreadability, pH, and in vitro antifungal activity in comparison with the free ITZ- gel. The prepared ITZ-TFS formulations exhibited high EE% ranging from 89.02 ± 1.65% to 98.17 ± 1.28% with particle size ranging from 132.6 ± 2.15 nm to 384.1 ± 3.46. The PDI for all ITZ-TFSs was less than 0.5 and had a negative zeta potential. The TEM image for the optimized formulation (ITZ-TFS4) showed spherical vesicles with a smooth surface. The prepared gels had good spreadability, pH, and acceptable drug content. ITZ-TFS gel showed higher antifungal activity than free ITZ gel as determined by zone of inhibition. ITZ was successfully prepared in form of TFSs with higher antifungal activity than the free drug.

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“…It was also effective in inhibiting thyrokinase and was well-tolerated in guinea pig test animals. These results suggest that catechin-containing transferosomes could be a potential treatment strategy for UV-induced oxidative damage to the skin through topical administration [74]. The liposomal form is considered to be the best protection against possible oxidation of polyphenolic compounds.…”

Section: Pre-clinical Dan Clinical Trials Of Catechins In Cosmetics A...mentioning

confidence: 87%

A Recent Update on the Potential Use of Catechins in Cosmeceuticals

Mita,

Husni,

Putriana

et al. 2024

Cosmetics

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Catechins are a type of flavonoid known for their beneficial functions as antioxidants and antibacterials. Recent research indicates the antioxidant potential of catechins on the skin. Catechin and epigallocatechin are reported to have significant potential in preventing ageing. Epigallocatechin gallate, gallocatechin gallate, and epigallocatechin can inhibit hyperpigmentation processes. Additionally, catechins exhibit potential in UV protection and inflammation inhibition in acne. Consequently, catechins are now being used in the cosmetics industry, with formulations containing catechins as the active ingredient developed to produce various products such as soap, sunscreen, creams, etc. Herein, this paper reviews the antioxidant potential of catechins for use in cosmetic formulations and the current status of clinical trials of catechins in cosmetics.

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Improved skin permeability and whitening effect of catechin-loaded transfersomes through topical delivery

Cited by 17 publications

References 29 publications

Synthesis and Evaluation of Alginate-Based Nanogels as Sustained Drug Carriers for Caffeine

Synthesis and Evaluation of Alginate-Based Nanogels as Sustained Drug Carriers for Caffeine

Preparation and Optimization of Itraconazole Transferosomes-Loaded HPMC Hydrogel for Enhancing Its Antifungal Activity: 2^3 Full Factorial Design

A Recent Update on the Potential Use of Catechins in Cosmeceuticals

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