2016
DOI: 10.1016/j.molstruc.2016.03.014
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Improved solubility and bioactivity of theophylline (a bronchodilator drug) through its new nitrate salt analysed by experimental and theoretical approaches

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Cited by 39 publications
(14 citation statements)
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“…Indeed, the combination of the various properties of organic materials (physico-chemical, biological, etc.) and the optical, thermal and electrical properties of inorganic particles has made it possible to prepare many materials for different practical fields especially: biology, pharmacology, optics, adhesives, surface modification, membranes [3][4][5][6][7][8]. Particularly the interaction of nitric acid with organic entities, the object of our work, gives rise to organic nitrates having important properties in biological systems namely, 1-methylpiperazine-1,4-diium bis(nitrate) [9], 1H-1,2,4-triazole-4-ium trioxonitrate…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, the combination of the various properties of organic materials (physico-chemical, biological, etc.) and the optical, thermal and electrical properties of inorganic particles has made it possible to prepare many materials for different practical fields especially: biology, pharmacology, optics, adhesives, surface modification, membranes [3][4][5][6][7][8]. Particularly the interaction of nitric acid with organic entities, the object of our work, gives rise to organic nitrates having important properties in biological systems namely, 1-methylpiperazine-1,4-diium bis(nitrate) [9], 1H-1,2,4-triazole-4-ium trioxonitrate…”
Section: Introductionmentioning
confidence: 99%
“…The synergy between the thermal, optical and / or electrical properties of inorganic particles and the physicochemical properties of organic materials opens a scope for these objects in various fields' namely optical, electrical conductivity and photochemistry [1][2][3][4][5][6]. The hybrid materials also penetrate application fields in the photo-catalysts [7,8] as well as biology [9][10][11] and medicine [12][13][14]. The structure of hybrid materials can be divided into two classes and in that function of levels of interaction between the organic and the inorganic phase [15].…”
Section: Introductionmentioning
confidence: 99%
“…24. By reference to the results of the assignment and to the bibliographic study [105][106][107][108] we have ascribed the different vibration modes of the nitrate anion (NO 3 -) and the organic cation to the set of bands that appeared in IR spectrum.…”
Section: Vibrational Analysismentioning
confidence: 99%
“…The synergy of the properties of these two components when they self-assemble in a crystalline state opens up a wide field of application in various domain, namely biology [1][2][3], optics, electrical conductivity, photochemistry [4][5][6][7][8][9], medicine [10][11][12], and photo catalysis [13,14]. Generally, heterocyclic compounds occupy a more interesting place in organic chemistry every day, so they are widely dispersed in nature and participate in important parts of many biochemical processes, especially in the medical field [15].…”
Section: Introductionmentioning
confidence: 99%