Improved solubility of lornoxicam by inclusion into SBA-15: Comparison of loading methods

Dadej, Adrianna; Woźniak-Braszak, Aneta; Bilski, P.; Piotrowska‐Kempisty, Hanna; Józkowiak, Małgorzata; Pawełczyk, Anna; Dadej, Daniela; Łażewska, Dominika; Jelińska, Anna

doi:10.1016/j.ejps.2022.106133

Cited by 10 publications

(6 citation statements)

References 44 publications

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“…Summing up, it can be concluded that the dose of 25 kGy causes little changes in the physicochemical properties of the drug, in contrast to the dose of 400 kGy, which causes decomposition of the drug. The HPLC method was used to determine the content of DC and AC before and after irradiation, which was validated according to the ICH guidelines [ 27 ]. In the chromatogram of the AC before irradiation, one peak with a retention time of 12.26 min, while for DC two signals with retention times of 1.75 min and 11.46 min were observed.…”

Section: Resultsmentioning

confidence: 99%

“…Within the concentration range from 0.5038 × 10 −4 to 6.0456 × 10 −4 g/mL for AC and 0.5014 × 10 −4 to 6.0168 × 10 −4 g/mL for DC the method was linear, characterized by a very good correlation coefficient (r = 0.9975–0.9978) and high precision (RSD = 1.07–1.15%). The method was validated according to the Guidelines of the International Conference on Harmonization [ 27 ]. The content of DC and AC was calculated by reference to the standard.…”

Section: Resultsmentioning

confidence: 99%

“…The 1H NMR experiments were performed on a pulse spectrometer operating at 25 MHz (El-Lab Tel-Atomic, Poznań, Poland) [ 24 , 25 , 26 , 27 ]. The non-irradiated and irradiated samples of DC and AC were sealed in glass tubes and degassed to remove humidity effects and paramagnetic oxygen.…”

Section: Methodsmentioning

confidence: 99%

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Electron Beam Radiation as a Safe Method for the Sterilization of Aceclofenac and Diclofenac—The Usefulness of EPR and 1H-NMR Methods in Determination of Molecular Structure and Dynamics

et al. 2022

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Diclofenac (DC) [2-(2,6-Dichloroanilino)phenyl]acetic acid,) and aceclofenac (AC) 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid in substantia were subjected to ionizing radiation in the form of a beam of high-energy electrons from an accelerator in a standard sterilization dose of 25 kGy and higher radiation doses (50–400 kGy). We characterized non-irradiated and irradiated samples of DC and AC by using the following methods: organoleptic analysis (color, form), spectroscopic (IR, NMR, EPR), chromatographic (HPLC), and others (microscopic analysis, capillary melting point measurement, differential scanning calorimetry (DSC)). It was found that a absorbed dose of 50 kGy causes a change in the color of AC and DC from white to cream-like, which deepens with increasing radiation dose. No significant changes in the FT-IR spectra were observed, while no additional peaks were observed in the chromatograms, indicating emerging radio-degradation products (25 kGy). The melting point determined by the capillary method was 153.0 °C for AC and 291.0 °C for DC. After irradiation with the dose of 25 kGy for AC, it did not change, for DC it decreased by 0.5 °C, while for the dose of 400 kGy it was 151.0 °C and 286.0 °C for AC and DC, respectively. Both NSAIDs exhibit high radiation stability for typical sterilization doses of 25–50 kGy and are likely to be sterilized with radiation at a dose of 25 kGy. The influence of irradiation on changes in molecular dynamics and structure has been observed by 1H-NMR and EPR studies. This study aimed to determine the radiation stability of DC and AC by spectrophotometric, thermal and chromatographic methods. A standard dose of irradiation (25 kGy) was used to confirm the possibility of using this dose to obtain a sterile form of both NSAIDs. Higher doses of radiation (50–400 kGy) have been performed to explain the changes in DC and AC after sterilization.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Electron Beam Radiation as a Safe Method for the Sterilization of Aceclofenac and Diclofenac—The Usefulness of EPR and 1H-NMR Methods in Determination of Molecular Structure and Dynamics

et al. 2022

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“…Our results are in line with previous reports. 7,68 For 24 h incubation, the toxic effect of Irinotecan, when adsorbed onto NPs pore framework, is amplified compared to Irinotecan in solution. Although the Irinotecan concentrations provided by each of the NPs suspensions are the same (10 µg mL −1 ), Iri@SBA-15 cytotoxicity (Fig.…”

Section: Cell Viabilitymentioning

confidence: 99%

Evaluation of intracellular distribution of folate functionalized silica nanoparticles using fluorescence and hyperspectral enhanced dark field microscopy

et al. 2022

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“…Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) having low aqueous solubility and high permeability through biological membranes leading to low bioavailability [1]. Several approaches such as complexation with cyclodextrins, solid dispersion, emulsion and cocrystallization are employed to enhance the solubility and subsequently bioavailability of active pharmaceutical ingredients (APIs).…”

Section: Introductionmentioning

confidence: 99%

Solubility Prediction of Lornoxicam in Different Pure Solvents Using Semi-Empirical Correlations and Thermodynamic Models

Kumar

Thakur²,

KULABHİ³

et al. 2023

International Journal of Thermodynamics

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The solubility data of Active Pharmaceutical Ingredients in organic solvents is an essential for pharmaceutical crystallization and drug formulation. In this work, two semi-empirical correlations- the Yaws model and λ-h model- and two thermodynamic models – Wilson Model and the Non-random two-liquid model- are used to estimate the solubility of lornoxicam in ethanol and water. The model parameters and correlations coefficients are calculated by optimizing the average relative deviation. The values of these parameters will be helpful to estimate the solubility of lornoxicam at different temperatures where the experimental solubility data is not available. The predicted solubility data of lornoxicam can be further utilized in the pharmaceutical crystallization and drug formulation.

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Improved solubility of lornoxicam by inclusion into SBA-15: Comparison of loading methods

Cited by 10 publications

References 44 publications

Electron Beam Radiation as a Safe Method for the Sterilization of Aceclofenac and Diclofenac—The Usefulness of EPR and 1H-NMR Methods in Determination of Molecular Structure and Dynamics

Electron Beam Radiation as a Safe Method for the Sterilization of Aceclofenac and Diclofenac—The Usefulness of EPR and 1H-NMR Methods in Determination of Molecular Structure and Dynamics

Evaluation of intracellular distribution of folate functionalized silica nanoparticles using fluorescence and hyperspectral enhanced dark field microscopy

Solubility Prediction of Lornoxicam in Different Pure Solvents Using Semi-Empirical Correlations and Thermodynamic Models

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