Improved spectral optical coherence tomography using optical frequency comb

Bajraszewski, Tomasz; Wojtkowski, Maciej; Szkulmowski, Maciej; Szkulmowska, Anna; Huber, Robert; Kowalczyk, Andrzej

doi:10.1364/oe.16.004163

Cited by 110 publications

(57 citation statements)

References 37 publications

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“…The generated solitons have pulse repetition rates of 20 GHz at both wavelengths. Such detectable and electronics-compatible repetition rate soliton microcombs at short wavelengths have direct applications in the development of miniature optical clocks 9,22,23 and potentially optical coherence tomography [24][25][26] . Also, any application requiring low-power near-visible mode-locked laser sources will benefit.…”

Section: Discussionmentioning

confidence: 99%

“…More generally, microcomb sources in the visible and ultra-violet bands could provide a miniature alternative to larger mode-locked systems such as titanium sapphire lasers in cases where high power is not required. It is also possible that these shorter wavelength systems could be applied in optical coherence tomography systems [24][25][26] . Efforts directed toward short wavelength microcomb operation include 1 µm microcombs in silicon nitride microresonators 27 as well as harmonically generated combs.…”

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confidence: 99%

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Towards Visible Soliton Microcomb Generation

Lee

Yang

et al. 2017

Nonlinear Optics

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Frequency combs have applications that extend from the ultra-violet into the mid-infrared bands. Microcombs, a miniature and often semiconductor-chip-based device, can potentially access most of these applications, but are currently more limited in spectral reach. Here, we demonstrate mode-locked silica microcombs with emission near the edge of the visible spectrum. By using both geometrical and mode-hybridization dispersion control, devices are engineered for soliton generation while also maintaining optical Q factors as high as 80 million. Electronics-bandwidth-compatible (20 GHz) soliton mode locking is achieved with low pumping powers (parametric oscillation threshold powers as low as 5.4 mW). These are the shortest wavelength soliton microcombs demonstrated to date and could be used in miniature optical clocks. The results should also extend to visible and potentially ultra-violet bands.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Towards Visible Soliton Microcomb Generation

Lee

Yang

et al. 2017

Nonlinear Optics

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“…In this process, the high frequency fringes are attenuated. Since the backscattered light from deeper objects creates higher frequency components in the interference pattern, the lowpass filtering results in a depth dependent attenuation [75]. This signal fall-off, which is sometimes called the sensitivity drop-off, causes the SNR of typical OCT images to drop quickly as depth increases.…”

Section: Lens Mechanismmentioning

confidence: 99%

“…Moreover, there are some imperfections, like the mismatch between the dispersion in the sample and reference arms, which eventually demands a software-based resampling process and cannot be solved readily by placing a prism in the spectrometer arm. Therefore, a software-based process would be essential to obtain a uniformly sampled signal in the frequency domain [75]. The majority of spectral-domain OCT systems perform the resampling as part of the OCT signal processing procedures.…”

Section: Detectormentioning

confidence: 99%

Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

Atry

Rosa

Rarick

et al. 2018

International Journal of Optics

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In the past decades, spectral-domain optical coherence tomography (SD-OCT) has transformed into a widely popular imaging technology which is used in many research and clinical applications. Despite such fast growth in the field, the technology has not been readily accessible to many research laboratories either due to the cost or inflexibility of the commercially available systems or due to the lack of essential knowledge in the field of optics to develop custom-made scanners that suit specific applications. This paper aims to provide a detailed discussion on the design and development process of a typical SD-OCT scanner. The effects of multiple design parameters, for the main optical and optomechanical components, on the overall performance of the imaging system are analyzed and discussions are provided to serve as a guideline for the development of a custom SD-OCT system. While this article can be generalized for different applications, we will demonstrate the design of a SD-OCT system and representative results for in vivo brain imaging. We explain procedures to measure the axial and transversal resolutions and field of view of the system and to understand the discrepancies between the experimental and theoretical values. The specific aim of this piece is to facilitate the process of constructing custom-made SD-OCT scanners for research groups with minimum understanding of concepts in optical design and medical imaging.

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“…Due to the large slope of the ocular surface, this drawback causes a decrease in signal-to-noise ratio (SNR) from the corneal apex to the sclera. Several approaches have been proposed to overcome this problem, such as phase shift techniques, 17,24,25 an optical frequency comb with additional tunable fiber Fabry-Perot interferometer, 26 and a spectrometer with special custom design. 27 Recently, OCT has been used to quantitatively measure the biometry of the anterior ocular segment.…”

Section: Introductionmentioning

confidence: 99%

Extended scan depth optical coherence tomography for evaluating ocular surface shape

Shen

Cui

et al. 2011

J. Biomed. Opt.

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Abstract. Spectral domain optical coherence tomography (SD-OCT) with extended scan depth makes it possible for quantitative measurement of the entire ocular surface shape. We proposed a novel method for ocular surface shape measurement using a custom-built anterior segment SD-OCT, which will serve on the contact lens fitting. A crosshair alignment system was applied to reduce the misalignment and tilting of the eye. An algorithm was developed to automatically segment the ocular surface. We also described the correction of the image distortion from the segmented dataset induced by the nontelecentric scanning system and tested the accuracy and repeatability. The results showed high accuracy of SD-OCT in measuring a bicurved test surface with a maximum height error of 17.4 μm. The repeatability of in vivo measurement was also good. The standard deviations of the height measurement within a 14-mm wide range were all less than 35 μm. This work demonstrates the feasibility of using extended depth SD-OCT to perform noninvasive evaluation of the ocular surface shape. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Improved spectral optical coherence tomography using optical frequency comb

Cited by 110 publications

References 37 publications

Towards Visible Soliton Microcomb Generation

Towards Visible Soliton Microcomb Generation

Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

Extended scan depth optical coherence tomography for evaluating ocular surface shape

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