Improved spectral quality for 3D MR spectroscopic imaging using a high spatial resolution acquisition strategy

Ebel, Andreas; Maudsley, Andrew A.

doi:10.1016/s0730-725x(02)00645-8

Cited by 86 publications

(107 citation statements)

References 17 publications

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“…We are unable to determine whether Glu in WM or GM is driving the correlation observed here. Future studies incorporating advanced MR techniques like short TE echo planar imaging EPSI (Ebel and Maudsley, 2003) are needed to differentiate white and gray matter Glu levels.…”

Section: Discussionmentioning

confidence: 99%

Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study

Wijtenburg

Wright

Korenic

et al. 2016

Neuropsychopharmacol

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The neurobiology of schizophrenia (SZ) may be altered in older versus younger adults with SZ, as less frequent episodes of symptom exacerbation and increased sensitivity to medications are observed in older age. The goal of this study was to examine the effect of age and diagnosis on glutamate and cerebral blood flow (rCBF) in adults with SZ and healthy controls. Young and older adults with SZ and healthy controls were recruited to participate in this study. Participants completed a neuropsychological battery and neuroimaging that included optimized magnetic resonance spectroscopy to measure anterior cingulate (AC) glutamate (Glu) and glutamine (Gln) and arterial spin labeling evaluation for rCBF. Regression analyses revealed significant effects of age with Glu, Gln, Gln/Glu, and AC white matter (WM) rCBF. Glu and WM rCBF decreased linearly with age while Gln and Gln/Glu increased linearly with age. Glu was lower in adults with SZ compared with healthy controls and in older adults versus younger adults but there was no interaction. Glu and WM rCBF were correlated with the UCSD Performance-Based Skills Assessment (UPSA) and processing speed, and the correlations were stronger in the SZ group. In the largest sample to date, lower Glu and elevated Gln/Glu levels were observed in adults with SZ and in older subjects. Contrary to expectation, these results do not show evidence of accelerated Glu aging in the anterior cingulate region in SZ compared with healthy controls.

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Section: Discussionmentioning

confidence: 99%

Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study

Wijtenburg

Wright

Korenic

et al. 2016

Neuropsychopharmacol

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“…The sequence included acquisition of a water MRSI data set, which was obtained using an interleaved acquisition using parameters identical with those for the metabolite MRSI, but with low flip-angle excitation and no water suppression. Additional details of the MRSI sequence have been provided elsewhere (7).…”

Section: Data Acquisitionmentioning

confidence: 99%

Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging

et al. 2006

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Image reconstruction for magnetic resonance spectroscopic imaging (MRSI) requires specialized spatial and spectral data processing methods and benefits from the use of several sources of prior information that are not commonly available, including MRI-derived tissue segmentation, morphological analysis and spectral characteristics of the observed metabolites. In addition, incorporating information obtained from MRI data can enhance the display of low-resolution metabolite images and multiparametric and regional statistical analysis methods can improve detection of altered metabolite distributions. As a result, full MRSI processing and analysis can involve multiple processing steps and several different data types. In this paper, a processing environment is described that integrates and automates these data processing and analysis functions for imaging of proton metabolite distributions in the normal human brain. The capabilities include normalization of metabolite signal intensities and transformation into a common spatial reference frame, thereby allowing the formation of a database of MR-measured human metabolite values as a function of acquisition, spatial and subject parameters. This development is carried out under the MIDAS project (Metabolite Imaging and Data Analysis System), which provides an integrated set of MRI and MRSI processing functions. It is anticipated that further development and distribution of these capabilities will facilitate more widespread use of MRSI for diagnostic imaging, encourage the development of standardized MRSI acquisition, processing and analysis methods and enable improved mapping of metabolite distributions in the human brain.

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“…The MRSI data were acquired using a 32-channel head coil as described previously. 10,16 DTI data (b 5 1,000 smm…”

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confidence: 99%

Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS

et al. 2013

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Objective: To demonstrate the sensitivity of a recently developed whole-brain magnetic resonance spectroscopic imaging (MRSI) sequence to cerebral pathology and disability in amyotrophic lateral sclerosis (ALS), and compare with measures derived from diffusion tensor imaging.Methods: Whole-brain MRSI and diffusion tensor imaging were undertaken in 13 patients and 14 agesimilar healthy controls. Mean N-acetylaspartate (NAA), fractional anisotropy, and mean diffusivity were extracted from the corticospinal tract, compared between groups, and then in relation to disability in the patient group.Results: Significant reductions in NAA were found along the course of the corticospinal tracts on whole-brain MRSI. There were also significant changes in fractional anisotropy (decreased) and mean diffusivity (increased) in the patient group, but only NAA showed a significant relationship with disability (r 5 0.65, p 5 0.01). Conclusion:Whole-brain MRSI has potential as a quantifiable neuroimaging marker of disability in ALS. It offers renewed hope for a neuroimaging outcome measure with the potential for harmonization across multiple sites in the context of a therapeutic trial. Neurology â 2013;80:610-615 GLOSSARY ALS 5 amyotrophic lateral sclerosis; ALSFRS-R 5 Amyotrophic Lateral Sclerosis Functional Rating Scale-revised; CST 5 corticospinal tract; DTI 5 diffusion tensor imaging; FA 5 fractional anisotropy; LMN 5 lower motor neuron; MD 5 mean diffusivity; MIDAS 5 Metabolite Imaging and Data Analysis System; MRSI 5 magnetic resonance spectroscopic imaging; NAA 5 N-acetylaspartate; OR 5 optic radiation; PLS 5 primary lateral sclerosis; TBSS 5 tract-based spatial statistics; WM 5 white matter.

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Improved spectral quality for 3D MR spectroscopic imaging using a high spatial resolution acquisition strategy

Cited by 86 publications

References 17 publications

Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study

Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study

Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging

Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS

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