Improved stability and biological activity of bacterioruberin in nanovesicles

Bio-based solvents as a sustainable alternative to develop a multiproduct biorefinery process from archaebacteria Halobacterium salinarum R1

“…The most valuable product recovered is bacterioruberin, a C50 carotenoid with high antioxidant activity. 49 Due to its properties and possible application in the pharmaceutical and cosmetic industries, GVL was considered as being part of an extract rich in bacterioruberin, without the need for solvent removal. A comprehensive diagram of the process contemplating all steps is proposed and presented in Fig.…”

More Than Pigments: The Potential of Astaxanthin and Bacterioruberin-Based Nanomedicines

“…In vivo: not reported In vitro: antioxidant, anti-inflammatory [55]; antiviral and anti-cancer activity [65] Cholinesterase [66], cyclooxygenase-2 [67], α-glucosidase, α-amylase, and pancreatic lipase [68] inhibition Beneficial effects on sperm cell viability [69] Antimicrobial activity against pathogenic bacteria and fungi [54,70,71]…”

“…All - trans BR has a membrane-spanning (hydrophobic part: 36 Å [ 137 ]), fully unsaturated isoprenoid chain [ 146 ], and the terminal OH groups interact with hydrophilic headgroups of polar lipids via H bonds, which allows a single BR molecule to connect the inner and outer leaflet of the membrane bilayer [ 147 ]. A recent work reports that BR extracted from H. tebenquichense (acetonic extract) inserts into the bilayer of archaeosomes (vesicles made of polar diethers archaeolipids extracted from H. tebenquichense ), slightly increasing its thickness, modifying the positions of the archaeolipids polar heads, and perturbing the longitudinal polyisoprenoid axe [ 55 ]. The monolayer-like BR is known also to stabilize the membrane of haloarchaea [ 137 ], possibly functioning as analogue to the membrane-spanning archaeal tetraethers [ 148 ], absent in halophilic archaea.…”