Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media

Mwila, Chiluba; Walker, Roderick B.

doi:10.3390/pharmaceutics12030234

Cited by 19 publications

(11 citation statements)

References 66 publications

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“…The findings from this research design indicate that drug:polymer (X1) and surfactant (X2) greatly affected FLS-MS. For the quadratic models, the superlative fit for t 50 % (Y1), Q90 (Y2) and percentage drug content (Y3) was observed owing to its highest r 2 in contrast to linear, Two Factor Interaction (2-FI) and cubic models [25,30] (Table 2). Hence, the quadratic approach was developed to identify the effects of variables on response parameters as shown:Yi=b0+b1X1+b2X2+b12X1X2+b1 3B showed a significant linear curve running through the origin, which confirmed that response parameters were conjunctiva with predicted value [23,24] .…”

Section: Resultsmentioning

confidence: 90%

“…Diagnostic plots were developed by Design-Expert software to investigate the goodness of fit of proposed model. Three-dimensional response surface graphs as well as corresponding two-dimensional contour graphs were developed using the Design-Expert software model graph tool to bestow graphical display of influence of independent variables on dependent parameters [23][24][25] .…”

Section: Statistical Diagnostic and Response Surface Analysis Of Experimental Data By Design-expert Softwarementioning

confidence: 99%

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Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres

Kanojia¹,

Singh²,

Sharma³

2021

ijps

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Kanojia et al.: Matrix Tablet of Fluvastatin Sodium MicrospheresThe purpose of this research is to investigate the suitability of acquiring improved dissolution profile and sustained release of Fluvastatin sodium to reduce dosage frequency via a novel combination of freeze dried microspheres and Eudragit polymers-based matrix tablet technologies. Fluvastatin sodium microspheres were prepared using polyvinyl pyrollidone K-30 and Poloxamer 407 through solvent evaporation via freeze drying. We adopted a central composite design to examine the influence of independent variables viz. drug:polymer (X1) and surfactant (X2) on the t 50 % (Y1), Q90 (Y2) and percentage drug content (Y3) along with determination of an optimized composition for production of an optimal Fluvastatin sodium microspheres. Design expert software illustrated that an optimized Fluvastatin sodium microspherescould be achieved using 1:3.496 drug:polymer and 3.102 % poloxamer 407 which would illustrates t 50 % (36.33 min), Q90 (79.99 %) and percentage drug content (81.589 %). The mean diameter and polydispersity index of Fluvastatin sodium microspheres using dynamic light scattering was found 0.78 µm and 0.287, respectively. Sustained release tablet of optimized Fluvastatin sodium microspheres (Fluvastatin sodium microspheres-sustained release tablet) was manufactured using Eudragit RS 100 and Eudragit RL 100 based granules by wet granulation technique. In vitro drug release kinetics studies were executed to assess the drug release mechanism from optimized Fluvastatin sodium microspheres and Fluvastatin sodium microspheres-sustained release tablet. The dissolution level of Fluvastatin sodium was 3.58-fold improved wthin 2 h through the freeze dried microspheres. Fluvastatin sodium microspheres-sustained release tablet showed sustained drug release over 24 h and was matched properly to Korsmeyer-Peppas model with release exponent of 0.5318, which indicated drug release through diffusion and erosion mechanism. Conclusively, it has been demonstrated that novel combination of freeze dried microspheres and their Eudragit polymers-based matrix tablet techniques could find great potential for improving drug dissolution and sustained release of water insoluble drugs along with reduced dosage frequency.

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Section: Resultsmentioning

confidence: 90%

Section: Statistical Diagnostic and Response Surface Analysis Of Experimental Data By Design-expert Softwarementioning

confidence: 99%

Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres

Kanojia¹,

Singh²,

Sharma³

2021

ijps

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“…KSL-W is a synthetic antibacterial peptide, which can effectively kill oral bacterial pathogens and inhibit oral biofilm formation. And the microsphere system prepared by PLGA can not only have an obviously sustained and controlled release effect on drugs, but also protect bioactive materials from the degradation of the corresponding environment and improve bioavailability, which has great potential for medical application [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

3D printed scaffold for repairing bone defects in apical periodontitis

Liu

Gao

et al. 2022

BMC Oral Health

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Objectives To investigate the feasibility of the 3D printed scaffold for periapical bone defects. Methods In this study, antimicrobial peptide KSL-W-loaded PLGA sustainable-release microspheres (KSL-W@PLGA) were firstly prepared followed by assessing the drug release behavior and bacteriostatic ability against Enterococcus faecalis and Porphyromonas gingivalis. After that, we demonstrated that KSL-W@PLGA/collagen (COL)/silk fibroin (SF)/nano-hydroxyapatite (nHA) (COL/SF/nHA) scaffold via 3D-printing technique exhibited significantly good biocompatibility and osteoconductive property. The scaffold was characterized as to pore size, porosity, water absorption expansion rate and mechanical properties. Moreover, MC3T3-E1 cells were seeded into sterile scaffold materials and investigated by CCK-8, SEM and HE staining. In the animal experiment section, we constructed bone defect models of the mandible and evaluated its effect on bone formation. The Japanese white rabbits were killed at 1 and 2 months after surgery, the cone beam computerized tomography (CBCT) and micro-CT scanning, as well as HE and Masson staining analysis were performed on the samples of the operation area, respectively. Data analysis was done using ANOVA and LSD tests. (α = 0.05). Results We observed that the KSL-W@PLGA sustainable-release microspheres prepared in the experiment were uniform in morphology and could gradually release the antimicrobial peptide (KSL-W), which had a long-term antibacterial effect for at least up to 10 days. HE staining and SEM showed that the scaffold had good biocompatibility, which was conducive to the adhesion and proliferation of MC3T3-E1 cells. The porosity and water absorption of the scaffold were (81.96 ± 1.83)% and (458.29 ± 29.79)%, respectively. Histological and radiographic studies showed that the bone healing efficacy of the scaffold was satisfactory. Conclusions The KSL-W@PLGA/COL/SF/nHA scaffold possessed good biocompatibility and bone repairing ability, and had potential applications in repairing infected bone defects. Clinical significance The 3D printed scaffold not only has an antibacterial effect, but can also promote bone tissue formation, which provides an alternative therapy option in apical periodontitis.

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“…In general the inclusion of polymers, lipids, and surfactants for the production of suitable carriers for medicinal and non-medicinal applications has been demonstrated and opportunities to produce technologies that exhibit advantages over conventional formulations including improved stability, enhanced and beneficial biodistribution profiles, altered drug release rates, lower immunotoxicity and with potential targeting of specific cells, exists [ 108 ]. Micro- and/or nano-encapsulation has been used to develop sustained/prolonged drug delivery technologies [ 30 , 109 , 110 ], minimise degradation in biological fluids [ 111 ], facilitate handling [ 112 ] reduce toxicity [ 109 , 113 , 114 , 115 ] and to improve the organoleptic properties [ 19 , 116 , 117 ] of products.…”

Section: Encapsulation and Evaluation Of Therapeutic Benefits Of Curmentioning

confidence: 99%

Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

et al. 2021

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There is a dearth of natural remedies available for the treatment of an increasing number of diseases facing mankind. Natural products may provide an opportunity to produce formulations and therapeutic solutions to address this shortage. Curcumin (CUR), diferuloylmethane; I,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione is the major pigment in turmeric powder which has been reported to exhibit a number of health benefits including, antibacterial, antiviral, anti-cancer, anti-inflammatory and anti-oxidant properties. In this review, the authors attempt to highlight the biological and pharmacological properties of CUR in addition to emphasizing aspects relating to the biosynthesis, encapsulation and therapeutic effects of the compound. The information contained in this review was generated by considering published information in which evidence of enhanced biological and pharmacological properties of nano-encapsulated CUR was reported. CUR has contributed to a significant improvement in melanoma, breast, lung, gastro-intestinal, and genito-urinary cancer therapy. We highlight the impact of nano-encapsulated CUR for efficient inhibition of cell proliferation, even at low concentrations compared to the free CUR when considering anti-proliferation. Furthermore nano-encapsulated CUR exhibited bioactive properties, exerted cytotoxic and anti-oxidant effects by acting on endogenous and cholinergic anti-oxidant systems. CUR was reported to block Hepatitis C virus (HCV) entry into hepatic cells, inhibit MRSA proliferation, enhance wound healing and reduce bacterial load. Nano-encapsulated CUR has also shown bioactive properties when acting on antioxidant systems (endogenous and cholinergic). Future research is necessary and must focus on investigation of encapsulated CUR nano-particles in different models of human pathology.

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Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media

Cited by 19 publications

References 66 publications

Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres

Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres

3D printed scaffold for repairing bone defects in apical periodontitis

Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

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