2017
DOI: 10.1097/mpg.0000000000001561
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Improved Starch Digestion of Sucrase‐deficient Shrews Treated With Oral Glucoamylase Enzyme Supplements

Abstract: Sucrase deficiency, in this model of congenital sucrase-isomaltase deficiency, reduces blood glucose response to starch feeding. Supplementing the diet with oral recombinant glucoamylase significantly improved starch digestion in the sucrase-deficient shrew.

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Cited by 8 publications
(10 citation statements)
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“…Moreover, all patients experienced a relapse of symptoms if the sacrosidase was not administered, and all six patients responded poorly to dietary modification 49 . The available literature proposing alternative enzyme replacement treatments for CSID in children is limited; however, Nichols et al demonstrated that there is a reduction of blood glucose in response to starch in shrews with CSID 7 . In this preclinical model, the use of oral recombinant glucoamylase significantly improved starch digestion 7 .…”
Section: Management Of Disaccharidase Deficiency In Ibsmentioning
confidence: 99%
See 2 more Smart Citations
“…Moreover, all patients experienced a relapse of symptoms if the sacrosidase was not administered, and all six patients responded poorly to dietary modification 49 . The available literature proposing alternative enzyme replacement treatments for CSID in children is limited; however, Nichols et al demonstrated that there is a reduction of blood glucose in response to starch in shrews with CSID 7 . In this preclinical model, the use of oral recombinant glucoamylase significantly improved starch digestion 7 .…”
Section: Management Of Disaccharidase Deficiency In Ibsmentioning
confidence: 99%
“…The available literature proposing alternative enzyme replacement treatments for CSID in children is limited; however, Nichols et al demonstrated that there is a reduction of blood glucose in response to starch in shrews with CSID 7 . In this preclinical model, the use of oral recombinant glucoamylase significantly improved starch digestion 7 . This model could be extended to treatment options for disaccharidase deficiencies in IBS.…”
Section: Management Of Disaccharidase Deficiency In Ibsmentioning
confidence: 99%
See 1 more Smart Citation
“…Hypotheses regarding the evolution of AGs in vertebrates have been shaped by work on mammals. In primates, rodents, and most other mammals that have been investigated (Pontremoli et al 2015;Nichols et al 2017), two enzymes are expressed in the intestinal "brush-border" membrane. Each enzyme has two similar subunits each with differing but overlapping catalytic activities (Nichols et al 2017).…”
Section: Introductionmentioning
confidence: 99%
“…In primates, rodents, and most other mammals that have been investigated (Pontremoli et al 2015;Nichols et al 2017), two enzymes are expressed in the intestinal "brush-border" membrane. Each enzyme has two similar subunits each with differing but overlapping catalytic activities (Nichols et al 2017). The active sites in maltase-glucoamylase (MGAM) hydrolyze the a-1,4 glycosidic bonds in maltose and in the small linear chains of glucose (amylose) that result from amylase's action on starch.…”
Section: Introductionmentioning
confidence: 99%