Improved Survival Following Thermal Injury in Adult Patients Treated at a Regional Burn Center

Gómez, Manuel; Cartotto, Robert; Knighton, Judy; Smith, Karen; Fish, Joel

doi:10.1097/bcr.0b013e31815f6efd

Cited by 89 publications

(24 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In thermal injury significant advances in burn management over the second half of the last century have resulted in considerable improvement in mortality but not in all age groups [106][107][108]. As a result mortality as an outcome measure has come under increasing criticism in recent years with calls for alternative parameters to monitor and improve the performance of burn services [109,110].…”

Section: Discussionmentioning

confidence: 98%

Predicting survival in thermal injury: A systematic review of methodology of composite prediction models

Hussain¹,

Choukairi

Dunn³

2013

Burns

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Predicting survival in thermal injury: A systematic review of methodology of composite prediction models

Hussain¹,

Choukairi

Dunn³

2013

Burns

View full text Add to dashboard Cite

“…Although mortality from major burn injuries has significantly decreased during the last decades, it remains high depending on injury severity, age, and body mass index [1][2][3]. Accurate prediction of prognosis in patients with a severe burn injury is important to allow appropriate treatment decisions by patients, relatives, and medical attendants.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-derived circulating free DNA (cf-DNA/NETs), a potential prognostic marker for mortality in patients with severe burn injury

Altrichter

Zedler

Kraft

et al. 2010

Eur J Trauma Emerg Surg

View full text Add to dashboard Cite

The predictive value of circulating free DNA/neutrophil extracellular traps (cf-DNA/NETs) has recently been shown in patients with major trauma for sepsis, multiple organ failure, and mortality. Here we report on the predictive potential of cf-DNA/NETs for mortality in patients with severe burn injury. In a prospective study 32 patients with severe burn injury were included. Blood samples were sequentially obtained on day 1, 3, 5, and 7 after admission. cf-DNA/NETs was directly quantified from plasma by means of rapid fluorescence assay. Time kinetics of cf-DNA/NETs were correlated with clinical data, C-reactive protein (CRP), procalcitonin (PCT), and interleukin (IL)-6. Furthermore sensitivity, specificity, and positive and negative predictive value, as well as receiver operation characteristic (ROC) curves were calculated. Seven patients died within the first month after burn injury. cf-DNA/NETs values from these patients were significantly increased already on day 1 and 3 after admission compared with patients who survived (p < 0.01). In contrast, PCT levels of nonsurvivors were significantly elevated on day 3 and 5 (p < 0.01), while CRP and IL-6 did not show any significant difference between survivors and nonsurvivors. At a cutoff of 255 ng/ml, cf-DNA/NETs had sensitivity of 0.8 and specificity of 0.74. ROC revealed largest areas under the curve (AUC) for cf-DNA/NETs on day 1 (0.851) and 3 (0.883) after admission. For all values between day 1 and 7, AUC was 0.815. cf-DNA/NETs seems to be a rapid, valuable marker for prediction of mortality in burn patients. A larger confirmation trial ought to be carried out.

show abstract

“…In Turkey, the mortality rate has been reported at 7.5% in recent studies. [6,7] In the USA, it has been reported that treatment of a patient with major burns costs $200,000. Globally, there are multidisciplinary studies that are being performed to increase the efficacy and reduce the costs of burn treatment.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Negative Pressure Wound Therapy in the Management of Acute Burns

Kement¹,

Başkıran

2018

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

Improved Survival Following Thermal Injury in Adult Patients Treated at a Regional Burn Center

Cited by 89 publications

References 36 publications

Predicting survival in thermal injury: A systematic review of methodology of composite prediction models

Predicting survival in thermal injury: A systematic review of methodology of composite prediction models

Neutrophil-derived circulating free DNA (cf-DNA/NETs), a potential prognostic marker for mortality in patients with severe burn injury

The Efficacy of Negative Pressure Wound Therapy in the Management of Acute Burns

Contact Info

Product

Resources

About