Improved survival in a retrospective cohort of 28 dogs with insulinoma

Polton, Gerry; White, R. N.; Brearley, M. J.; Eastwood, J. M.

doi:10.1111/j.1748-5827.2006.00187.x

Cited by 92 publications

(164 citation statements)

References 10 publications

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“…Depending on the study, the sensitivity of conventional ultrasonography for detecting pancreatic insulinomas is 28-75% in dogs. 4,[29][30][31][32] In a case series of 14 dogs with insulinomas, CT showed a higher sensitivity for detecting insulinoma mass lesions than that of conventional ultrasonography. 4 In humans, the sensitivity of transabdominal ultrasonography for localizing pancreatic insulinomas is 9-64%.…”

Section: Discussionmentioning

confidence: 99%

Contrast‐enhanced Ultrasonographic Findings in Three Dogs With Pancreatic Insulinoma

Nakamura

Lim

Ochiai

et al. 2014

Vet Radiology Ultrasound

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Abdominal ultrasonography is one of the most common diagnostic imaging modalities used for dogs with suspected insulinoma; however, pancreatic masses are clearly identified in fewer than half of affected dogs and benign pancreatic nodules can be difficult to differentiate from malignant ones. The purpose of this prospective study was to describe contrast-enhanced ultrasonography (CEUS) characteristics of confirmed pancreatic insulinoma in a group of dogs. Inclusion criteria were as follows: (1) repeated hypoglycemia (blood glucose levels <60 mg/dl, twice or more); (2) elevated blood insulin levels with hypoglycemia; (3) pancreatic nodules detected with conventional ultrasonography; and (4) histological confirmation of pancreatic islet cell carcinoma. Immediately following conventional ultrasonography of the entire abdomen, CEUS of the pancreatic nodule and adjacent parenchyma was performed using contrast-specific technology pulse inversion imaging and perflubutane microbubble contrast agent. Three dogs met inclusion criteria. Pancreatic nodules in all the three dogs became more clearly demarcated after injection of the contrast agent. Each nodule showed different enhancement patterns: markedly hyperechoic for 5 s, slightly hyperechoic for 1 s, and clearly hypoechoic for over 30 s. These results were not in complete agreement with previously reported CEUS findings in human patients with insulinoma. All nodules were surgically resected and histopathologically confirmed as malignant insulinomas. Findings from the current study indicated that contrast-enhanced ultrasound may help to increase conspicuity of pancreatic insulinomas in dogs and that enhancement characteristics may be more variable in dogs than in humans.

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Section: Discussionmentioning

confidence: 99%

Contrast‐enhanced Ultrasonographic Findings in Three Dogs With Pancreatic Insulinoma

Nakamura

Lim

Ochiai

et al. 2014

Vet Radiology Ultrasound

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“…Our present series of carcinomas included 3 cases without metastases (clinical stage 1), 2 cases of carcinoma with metastasis to associated lymph nodes at surgery (clinical stage 2), and 3 cases with hepatic metastases (clinical stage 3). All cases were within the 95% confidence interval of median survival times for insulinoma in each clinical stage as reported in another recent retrospective study [15].…”

Section: Discussionmentioning

confidence: 99%

“…For the treatment of canine insulinoma, the efficacy of medical treatments after surgery has been suggested [4,15], but surgical treatment after clinical diagnosis remains the treatment of choice [4,13,15].…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Study of Canine Insulinomas: Eight Cases (2005-2008)

et al. 2009

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ABSTRACT. This retrospective study examined 8 cases of pathologically diagnosed insulinoma. Surgical intervention was performed in all cases, once insulinoma was suspected based on unique clinical signs, hypoglycemia, and/or findings on ultrasonography. At the same time, insulin and glucose concentrations were measured before surgery for clinical diagnosis. Although all cases displayed typical clinical signs and hypoglycemia, insulin concentrations varied with 3 of 8 cases showing levels within the reference interval. In addition, to confirm the reliability of measured values, we submitted serum samples from 4 cases to two commercial veterinary laboratories. Results differed considerably between laboratories, with no apparent correlations between the two. In Laboratory A, 3 of 4 cases were above the reference interval, and 1 case was in the middle of the reference interval. Conversely, in Laboratory B, 3 of 4 cases were above the reference interval, and 1 case was below the reference interval. Split decisions regarding the diagnosis of insulinoma were seen for 2 of the 4 cases.

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“…Ki67 is a proliferation marker expressed during the active phases of the cell cycle and absent in resting cells (Scholzen and Gerdes, 2000). Polton, et al, (2007) reported a median disease free interval of 496 days (95% CI: 302 to 690 days) in 19 dogs that underwent partial pancreatectomy. Tobin and colleagues (1999) reported median survival time after diagnosis of 74 days (range, 8 to 508 days) and 381 days (range, 20 to 1758) in dogs treated medically versus dogs that initially underwent surgery followed by medical treatment, respectively.…”

Section: Prognosismentioning

confidence: 99%

Beta-Cell Neoplasia: Insulinoma

Nelson¹

2015

Canine and Feline Endocrinology

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Improved survival in a retrospective cohort of 28 dogs with insulinoma

Cited by 92 publications

References 10 publications

Contrast‐enhanced Ultrasonographic Findings in Three Dogs With Pancreatic Insulinoma

Contrast‐enhanced Ultrasonographic Findings in Three Dogs With Pancreatic Insulinoma

Retrospective Study of Canine Insulinomas: Eight Cases (2005-2008)

Beta-Cell Neoplasia: Insulinoma

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