2003
DOI: 10.1016/s1062-1458(02)01082-6
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Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients

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Cited by 272 publications
(345 citation statements)
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“…Tweddell et al [16] reported improvement in hospital survival from 53% in the operations performed between 1992 and the middle of 1996, to 93% in a series of 81 patients submitted to the Norwood operation using mBT grafts between July 1996 and October 2001. It must be mentioned, however, that this series was not made up of only infants with classical HSLS; 23% had anatomical variants that resulted in the left ventricle becoming the systemic ventricle.…”
Section: Discussionmentioning
confidence: 99%
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“…Tweddell et al [16] reported improvement in hospital survival from 53% in the operations performed between 1992 and the middle of 1996, to 93% in a series of 81 patients submitted to the Norwood operation using mBT grafts between July 1996 and October 2001. It must be mentioned, however, that this series was not made up of only infants with classical HSLS; 23% had anatomical variants that resulted in the left ventricle becoming the systemic ventricle.…”
Section: Discussionmentioning
confidence: 99%
“…Cyanosis, cardiac insufficiency and preexisting abnormities of the central nervous system that are associated with HSLS, as well as CPB and hypothermic circulatory arrest used in the staged correction, can cause neurological damage. Low flow selective cerebral perfusion has been used by some groups as an alternative to total circulatory arrest [16,19]. Data from a randomized pilot study did not suggest that selective cerebral perfusion improves the neuropsychomotor development of children submitted to the Norwood operation, when compared to hypothermic circulatory arrest [20].…”
Section: Discussionmentioning
confidence: 99%
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“…Of all congenital anomaly subgroups, the highest rate of infant deaths is associated with CHDs, and this may account for the greater interest in monitoring outcomes after hospital discharge. It is also notable that postdischarge outcomes of infants with CHDs came to prominence with the introduction of staged palliative surgery for HLHS, which led to improved early in-hospital outcomes 40,41 and highlighted later interstage mortality as an important concern. 15,26 A limitation of our review was the rigour of our eligibility criteria, which excluded any studies that did not clearly differentiate between deaths that occurred before and after hospital discharge, and thus may have excluded from the review some studies that evaluated additional risk factors to those reported here.…”
Section: Context and Limitationsmentioning
confidence: 99%
“…Sie kann durch die Überwachung der Sauerstoffausschöpfung (S cv O 2 in der V. cava superior) oder durch ein Monitoring der zerebralen und der Splanchnikusperfusion mithilfe einer "near-infrared spectroscopy" (NIRS)unterstützt werden [327,328,329]. Die Behandlung eines hohen systemischen Gefäßwiderstands mit einer α-adrenergen Rezeptor-Blockade kann den systemischen Sauerstofftransport verbessern [330], die Inzidenz einer kardiovaskulären Dekompensation verringern [331] und die Überlebensrate erhöhen [332].…”
Section: Univentrikuläres Herz (Nach Erster Korrekturoperation)unclassified