Improved susceptibility weighted imaging at ultra-high field using bipolar multi-echo acquisition and optimized image processing: CLEAR-SWI

Eckstein, Korbinian; Bachratá, Beáta; Hangel, Gilbert; Widhalm, Georg; Enzinger, Christian; Barth, Markus; Trattnig, Siegfried; Robinson, Simon

doi:10.1016/j.neuroimage.2021.118175

Cited by 27 publications

(26 citation statements)

References 82 publications

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-weighted magnitude ( Gulban et al, 2021 ) or phase imaging ( Fan et al, 2015 ), SWI ( Eckstein et al, 2021 ; Reichenbach et al, 1997 ), or quantitative susceptibility mapping (QSM) ( Bernier et al, 2018 ; Huck et al, 2019 ; Mattern et al, 2019 ; Ward et al, 2018 )—would enable a comprehensive assessment of the complete cortical vasculature and how both arteries and veins shape brain hemodynamics.…”

Section: Discussionmentioning

confidence: 99%

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Bollmann

Mattern

Bernier

et al. 2022

eLife

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The pial arterial vasculature of the human brain is the only blood supply to the neocortex, but quantitative data on the morphology and topology of these mesoscopic arteries (diameter 50-300µm) remains scarce. Because it is commonly assumed that blood flow velocities in these vessels are prohibitively slow, non-invasive time-of-flight MRI angiography (TOF-MRA)-which is well-suited to high 3D imaging resolutions-has not been applied to imaging the pial arteries. Here, we provide a theoretical framework that outlines how TOF-MRA can visualize small pial arteries in vivo, by employing extremely small voxels at the size of individual vessels. We then provide evidence for this theory by imaging the pial arteries at 140-µm isotropic resolution using a 7T MRI scanner and prospective motion correction, and show that pial arteries one voxel-width in diameter can be detected. We conclude that imaging pial arteries is not limited by slow blood flow, but instead by achievable image resolution. This study represents the first targeted, comprehensive account of imaging pial arteries in vivo in the human brain. This ultra-high-resolution angiography will enable the characterization of pial vascular anatomy across the brain to investigate patterns of blood supply and relationships between vascular and functional architecture.

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Section: Discussionmentioning

confidence: 99%

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Bollmann

Mattern

Bernier

et al. 2022

eLife

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show abstract

“…While the same theoretical considerations apply, imaging the arterial vasculature in these structures will require even smaller voxel sizes due to their smaller arterial diameters (Duvernoy et al, 1983, 1981; Nonaka et al, 2003a). In addition, imaging of the pial venous vasculature—using susceptibility-based contrasts such as T 2 * - weighted magnitude (Gulban et al, 2021) or phase imaging (Fan et al, 2015), susceptibility-weighted imaging (SWI) (Eckstein et al, 2021; Reichenbach et al, 1997) or quantitative susceptibility mapping (QSM) (Bernier et al, 2018; Huck et al, 2019; Mattern et al, 2019; Ward et al, 2018)—would enable a comprehensive assessment of the complete cortical vasculature and how both arteries and veins shape brain hemodynamics.…”

Section: Discussionmentioning

confidence: 99%

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Bollmann

Mattern

Bernier

et al. 2021

Preprint

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The pial arterial vasculature of the human brain is the only blood supply to the neocortex, but quantitative data on the morphology and topology of these mesoscopic vessels (diameter 50-300 μm) remains scarce. Because it is commonly assumed that blood flow velocities in these vessels are prohibitively slow, non-invasive time-of-flight MRI angiography (TOF-MRA)-which is well-suited to high 3D imaging resolutions-has not been applied to imaging the pial arteries. Here, we provide a theoretical framework that outlines how TOF-MRA can visualize small pial arteries in vivo, by employing extremely small voxels at the size of individual vessels. We then provide evidence for this theory by imaging the pial arteries at 140-μm isotropic resolution using a 7T MRI scanner and prospective motion correction, and show that pial arteries one voxel-width in diameter can be detected. We conclude that imaging pial arteries is not limited by slow blood flow, but instead by achievable image resolution. This study represents the first targeted, comprehensive account of imaging pial arteries in vivo in the human brain. This ultra-high-resolution angiography will enable the characterization of pial vascular anatomy across the brain to investigate patterns of blood supply and relationships between vascular and functional architecture.

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“…To generate susceptibility maps, the multi-echo images were combined over echoes using inverse-variance weighting. 29 , 62 , 63 Phase unwrapping was performed using ROMEO. 57 , 58 Background-field correction was performed with PDF 64 and susceptibility calculation with STAR 65 using the Sepia toolbox.…”

Section: Methodsmentioning

confidence: 99%

Quantitative susceptibility mapping of the head‐and‐neck using SMURF fat‐water imaging with chemical shift and relaxation rate corrections

Bachratá

Trattnig

Robinson

2021

Magnetic Resonance in Med

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Improved susceptibility weighted imaging at ultra-high field using bipolar multi-echo acquisition and optimized image processing: CLEAR-SWI

Cited by 27 publications

References 82 publications

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Quantitative susceptibility mapping of the head‐and‐neck using SMURF fat‐water imaging with chemical shift and relaxation rate corrections

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