Purpose Rising demand of fish generates various pressures on aquatic ecosystems, causing its deterioration and the loss of its biodiversity. With the aim of a better management and fish production in a salubrious environment, this study proposes the utilization of organic fertilizers from rabbit manure. Methods The treatments consisted of manure of rabbits fed with: manufactured diet (T 1 ), improved diet with Ipomea aquatic (T 2 ), improved diet with Elaeis guineensis (T 3 ), and improved diet with Panicum maximum (T 4 ). Indeed, experimental design was a completely randomized block design with three replications. 6 g in 10 L of water from the different manures from each diet was followed during 50 days. Various nutrients were measured. Results After the mineralization process, the best manure which released more nutrients was T 4 with measured proportions of N-NO 2 -, N-NO 3 -, N-NH 3 , P-PO 4 3-, Ca 2? , Mg 2? , K ? , and suspended matter being 0.06 ± 0.0, 0.38 ± 0.1, 0.85 ± 0.1, 8.27 ± 0.9, 12.11 ± 0.8, 4.47 ± 0.3, 3.02 ± 0.2, and 140.78 ± 18.6 mg/L, respectively. The highest content of phosphorus and nitrogen was recorded in T 4 and T 2 , respectively. The principal component analysis showed a positive correlation between P-PO 4 3-, Ca 2? , Mg 2? , MES, conductivity, and salinity during mineralization.Conclusion Manure from rabbits fed by an improved diet with P. maximum (T 4 ) was recommended for agro-piscicultural production system.