Improved syntheses of ethyl 3,3,3-trifluoropropionate and 3,3,3-trifluoropropionic acid

Abstract

Ethyl 3,3,3-trifluoropropionate was synthesized by treatment of monoethylmalonate with sulfur tetrafluoride. 3,3,3-Trifluoropropionic acid was prepared by acid hydrolysis. The physical properties of these compounds are compared to the literature values.Our continuing research on the synthesis and reactions of fluorinated nitroaliphatic compounds (9, 10), required ethyl 3,3,3-trifluoropropionate (II) in relatively large quan-

Suicide inactivation of fructose 1,6-bisphosphate aldolase

“…DHAP as dimethyl ketal, FDP, GSH, and NADH were obtained from Boehringer (Mannheim). GAP as diethyl ketal, DTNB, and DTT were purchased from Sigma Chemical Co. Ethyl 3,3,3-trifiuoropropionate was prepared by Dr. Lantz (ATOCHEM, Lyon), hydrolyzed to the acid (Peters et al, 1971), and transformed to the corresponding acid chloride by action of phosphorus pentachloride (Henne et al, 1955).…”