1999
DOI: 10.1016/s0957-4166(99)00441-3
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Improved synthetic methods of CP-060S, a novel cardioprotective drug

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Cited by 44 publications
(38 citation statements)
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“…The regiocontrol in the cyclization of thioureas bearing an aroyl and an aryl substituent is typically influenced by thermodynamic stability of regioisomer 2 over 3. This has also been supported by H NMR δ/ppm (J Hz) 13 C NMR δ/ppm the bond length of 1.3775 for N2-C9 compared to a bond length of 1.3827 for N2-C11 showing a partial double bond nature of the former.…”
Section: Resultsmentioning
confidence: 52%
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“…The regiocontrol in the cyclization of thioureas bearing an aroyl and an aryl substituent is typically influenced by thermodynamic stability of regioisomer 2 over 3. This has also been supported by H NMR δ/ppm (J Hz) 13 C NMR δ/ppm the bond length of 1.3775 for N2-C9 compared to a bond length of 1.3827 for N2-C11 showing a partial double bond nature of the former.…”
Section: Resultsmentioning
confidence: 52%
“…δ 9 and 12 for HN(1) and HN(3) and peaks at ca. δ 170 and 179 for carbonyl and thiocarbonyl were observed in the 1 H and 13 CNMR spectra respectively. The next step involving the base-catalyzed cyclization of 1-aroyl-3-arylthioureas with chloroacetyl chloride may lead to different condensation products by S or N intramolecular cyclization by a slight variation of conditions; therefore, it is important to first unearth the set of optimized conditions.…”
Section: Resultsmentioning
confidence: 99%
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“…Thiazolidine-4-one derivatives are known to exhibit diverse bioactivities such as anti-convulsant, 17) antidiarrheal, 18) antiplatelet activating factor, [19][20][21] anti-histaminic, 22,23) antimicrobial, 24,25) anti-diabetic, 26) cyclooxygenase (COX) inhibitory, 27) Ca 2ϩ -channel blocker, 28) platelet activating factor (PAF) antagonist, 29) cardioprotective, 30) anti-ischemic, 31) anticancer, 32) tumour necrosis factor-a antagonist 33) and nematicidal activities. 34) Nematodes are tiny worms, some of them are plant parasites and can play an important role in the predisposition of the host plant to the invasion by secondary pathogens.…”
Section: )mentioning
confidence: 99%
“…[8][9][10] The thiazolidine-4-one ring also occurs in nature; thus actithiazic acid isolated from Streptomycis strains exhibits highly specific in vitro activity against mycobacteri-um Tuberculosis. 11 Thiazolidine-4-ones are known to exhibit diverse bioactivities, such as antiplatelet activating factor, 12 antihistaminic, 13 COX inhibitory, 14 Ca +2 channel blocking, 15 PAF antagonist, 16 cardioprotective, 17 anti-ischemic 18 and nematicidal activities. 19 Moreover, pyrazoles and their derivatives could be considered as possible antimicrobial agents.…”
Section: Introductionmentioning
confidence: 99%