Improved thickness measurement method for choroidal hyperpermeability in central serous chorioretinopathy

Chen, Xingwang; Han, Fang-Yuan; Su, Gang; Pan, Le; Cai, Sanjun

doi:10.18240/ijo.2020.09.10

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…It has been postulated that the inner retinal layer in CCSC is affected by choroidal hyperpermeability and an associated increase in pachychoriod and thus may be more complex and variable than that in RCSC. Furthermore, previous studies have indicated that retinal and choroidal blood flow is varied when the retina is detached [37][38] . The superficial capillary plexus (SCP) is primarily located within the ganglion cell layer.…”

Section: Discussionmentioning

confidence: 99%

“…Retinal circuits transform the pixel representation of photoreceptors into the feature representations of ganglion cells, whose axons, bodies and dendrites transmit these representations to the brain and contribute to a variety of visual perception effects [42] . Neurons are extremely sensitive to oxidative stress damage, and an imbalance in reactive oxygen species is often involved in CSC as one of the postulated pathogeneses [38,[43][44] . CSC patients have a low arterial blood flow velocity and blood flow volume in the posterior ciliary artery, and circulation from the ophthalmic artery to the choriocapillaris is impaired, probably suggesting poor choroidal blood perfusion [45] .…”

Section: Discussionmentioning

confidence: 99%

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Detection of macular ganglion cell complex loss and correlation with choroidal thickness in chronic and recurrent central serous chorioretinopathy

Liu¹,

Wang²,

Chen³

2023

Int J Ophthalmol

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AIM: To investigate the association of ganglion cell complex thickness (GCCt), global loss volume percentage (GLV%), and focal loss volume percentage (FLV%) with structural and functional findings among patients with chronic central serous chorioretinopathy (CCSC) and recurrent central serous chorioretinopathy (RCSC) by optical coherence tomography (OCT). METHODS: Among 29 patients with monocular affected central serous chorioretinopathy (CSC), 15 had CCSC, and 14 had RCSC. The GCCt, FLV%, GLV%, and subfoveal choroidal thickness (SFCT) and sublesional choroidal thickness (SLCT) values were determined using OCT, and the association of these characteristics with neural structure parameters, choroidal morphology, features and functional alterations were estimated for the CCSC and RCSC patients. RESULTS: In CCSC, the affected eyes had significantly lower GCCt values than the fellow eyes in the macular regions (all P<0.05), with the highest GCCt observed in the inferior area. A significant association was found between the GCCt in different regions and the change in best corrected visual acuity (BCVA; r=-0.696; -0.695; -0.694, P<0.05) in CCSC patients. A statistically significant moderate negative correlation indicated that long-term CCSC was associated with greater differences in the GCCt in different regions between affected and fellow eyes (r=-0.562; r=-0.556; r=0.525, P<0.05). Additionally, observation of thickened SFCT was associated with a worse FLV% (r=0.599; r=0.546, P<0.05) in both groups. Similarly, thickened SLCT was associated with FLV% in RCSC patients (r=0.544, P<0.05). CONCLUSION: The distribution and GCCt are associated with the duration and visual outcomes of CCSC, whereas there is no correlation among RCSC patients. FLV% may be instrumental in differentiating the various outer choroidal vessels (pachyvessels) in long-term CSC. These results suggest that neural structure parameters may aid in estimating and predicting the recovery of altered morphology and function in CCSC and RCSC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Detection of macular ganglion cell complex loss and correlation with choroidal thickness in chronic and recurrent central serous chorioretinopathy

Liu¹,

Wang²,

Chen³

2023

Int J Ophthalmol

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“…The first measurement of CT was performed over 100 years ago on casts of autopsy eyes; however, this method itself had unknown effects on the choroid and CT measurements [ 10 ]. Modern methods of assessment include indocyanine green angiography (ICG) [ 11 , 12 ], B-scan ultrasonography [ 13 ], and more recently, applications of EDI-OCT [ 14 ] and swept-source OCT (SS-OCT) [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review

Vercellin

Harris

Stoner

et al. 2022

JCM

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The choroid provides the majority of blood flow to the ocular tissues and structures that facilitate the processes of retinal metabolism responsible for vision. Specifically, the choriocapillaris provides a structural network of small blood vessels that supplies the retinal ganglion cells and deep ocular tissues. Similar to retinal nerve fiber layer thickness, choroidal thickness (CT) has been suggested to represent a quantifiable health biomarker for choroidal tissues. Glaucoma is a disease with vascular contributions in its onset and progression. Despite its importance in maintaining ocular structure and vascular functionality, clinical assessments of choroidal tissues have been historically challenged by the inaccessibility of CT biomarker targets. The development of optical coherence tomography angiography and enhanced depth imaging created a framework for assessing CT and investigating its relationship to glaucomatous optic neuropathy onset and progression. Pilot studies on CT in glaucoma are conflicting—with those both in support of, and against, its clinical utility. Complicating the data are highly customized analysis methods, small sample sizes, heterogeneous patient groups, and a lack of properly designed controlled studies with CT as a primary outcome. Herein, we review the available data on CT and critically discuss its potential relevance and limitations in glaucoma disease management.

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Improved thickness measurement method for choroidal hyperpermeability in central serous chorioretinopathy

Cited by 2 publications

References 23 publications

Detection of macular ganglion cell complex loss and correlation with choroidal thickness in chronic and recurrent central serous chorioretinopathy

Detection of macular ganglion cell complex loss and correlation with choroidal thickness in chronic and recurrent central serous chorioretinopathy

Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review

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