This study aims to investigate the microstructural and wear properties of WC-Co coating deposited by High-Velocity Oxy-Fuel Spraying (HVOF) by optimising powders with different content ratios. Stainless steel, which is widely used in the industry, was selected as the substrate for testing. The study looked into the parameters of the HVOF process, such as powder type, nozzle distance, and the number of passes. Two different powders were used as coating powder, one containing 50wt.% Sulzer Metco 5810 (WC, wt.%12 Cobalt powder) and 50wt.% Amdry 960 (Ni, Cr, Al), and the other containing 50 wt.% Woka 3653 and 50 wt.% Amdry 960. The coating layer was examined using SEM-EDS, and XRD analyses were applied to the coated surface. The hard phases occurred after the HVOF process, and the hardness values were measured on the cross-section of the coating layer. The coated surface's hardness was found to be increased by five times. The CSM wear tests machine examined the changes in the wear properties of stainless steel according to ASTM G133 standard. Both coatings positively affected wear, and the wear resistance of the coated surface was increased after the HVOF process. The friction coefficients of samples decreased after the coating process. SEM-EDS analyses of worn surfaces were conducted, and a 3D surface topography test was applied to worn surfaces.