Improved Ultra-Performance LC Determination of Indapamide in Human Plasma

Ateş, Z.; Özden, Tuncel; Ozilhan, Selma; Eren, Şule

doi:10.1365/s10337-007-0300-0

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…The method did not offer any improvement over any of the previously reported methods, e.g. [27]. However, the TUV detector is considered to have better sensitivity than PDA detector.…”

Section: Bioequivalence Study and Drug Screeningmentioning

confidence: 62%

“…In an approach to study the Pharmacokinetic (PK) and bioequivalence of Indp tablets in the drug-free human plasma (obtained from healthy male volunteers of Ibni-Sina hospital, Ankara, Turkey) within a 96 h period, Ates ¸et al [27] extracted Indp and sulfamethazine (internal standard) by LLE with Et 2 O from plasma. UPLC system equipped with Tunable UV (TUV) detector and C 18 column (L 3 i.d., 100 3 2.1, 1.7 μm) using MeCN-phosphate buffer flowing at 0.5 mL min À1 with gradient composition in 07 min was successful for separation and detection in UV at 241 nm.…”

Section: Bioequivalence Study and Drug Screeningmentioning

confidence: 99%

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Chromatographic methods and approaches for bioequivalence study, drug screening and enantioseparation of indapamide

Sethi

Martens

Bhushan

2024

AChrom

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Indapamide (Indp) and certain other diuretics have been abused in sports, therefore, having sensitive methods for its detection and assay in biological fluids (whole blood, plasma, serum, and urine) is of significant importance. The racemic mixture of Indp is being used as an active pharmaceutical ingredient among other commonly prescribed diuretics. The regulatory authorities and pharmaceutical industries demand analytical methods for successful enantioseparation of such molecules. The paper presents a critical overview of the scientific issues of the application of contemporary techniques involving various chromatographic approaches (with liquid or supercritical fluid as mobile phases) and capillary electrophoresis and method development, for drug screening, assay, bioequivalence studies and enantioseparation of indapamide with their results. It also covers the historical developments that led to significant breakthroughs in research and concise evaluations of research in the area.Different types of chromatographic methods (HPLC, CEC, SFC etc) discussed herein provide an insight and a choice to select a method to (i) screen Indp for drug abuse, (ii) separate, isolate and quantify the enantiomers of Indp and (iii) investigate their pharmacokinetics as markedly different species and not as a total drug. The article evaluates the field's status with a broad base and practical oriented approach so that the underlying principles are easily understood to help chemists and non-specialists gain useful insights into the field outside their specialization and provide experts with summaries of key developments. To the best of authors' knowledge there has been no attempt to review such methods for analysis of Indp and this is the first report of its kind.

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“…The method did not offer any improvement over any of the previously reported methods, e.g. [27]. However, the TUV detector is considered to have better sensitivity than PDA detector.…”

Section: Bioequivalence Study and Drug Screeningmentioning

confidence: 62%

Section: Bioequivalence Study and Drug Screeningmentioning

confidence: 99%