2008
DOI: 10.1016/j.ejps.2008.02.002
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Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model

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Cited by 26 publications
(22 citation statements)
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References 29 publications
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“…The two enantiomers of VER had a jejunal P eff of approximately 1 ϫ 10 Ϫ4 cm/s, which is in agreement with jejunal P eff data from a previous perfusion study in the same pig model (Petri et al, 2006). Compared with the P eff values for other substances in this model (Petri et al, 2006;Persson et al, 2008), it classifies both enantiomers of VER as high-permeability drugs in pigs. In general, the P eff values obtained in the pig model are lower than reported jejunal P eff values (in vivo) in humans.…”
Section: Discussionsupporting
confidence: 77%
See 1 more Smart Citation
“…The two enantiomers of VER had a jejunal P eff of approximately 1 ϫ 10 Ϫ4 cm/s, which is in agreement with jejunal P eff data from a previous perfusion study in the same pig model (Petri et al, 2006). Compared with the P eff values for other substances in this model (Petri et al, 2006;Persson et al, 2008), it classifies both enantiomers of VER as high-permeability drugs in pigs. In general, the P eff values obtained in the pig model are lower than reported jejunal P eff values (in vivo) in humans.…”
Section: Discussionsupporting
confidence: 77%
“…The surgery was performed using a previously reported procedure (Petri et al, 2006;Persson et al, 2008;Sjödin et al, 2008). The abdominal cavity was opened through a midline incision.…”
Section: Methodsmentioning
confidence: 99%
“…Throughout the experiment body temperature, blood gases, electrocardiograms, heart rate, hemoglobin, and arterial and central venous pressures were monitored to ensure normal physiological values. As the animal model was carefully monitored the physiological conditions were comparable with those of previous studies (Petri et al, 2006;Persson et al, 2007Persson et al, , 2008Sjödin et al, 2008). …”
Section: Methodssupporting
confidence: 50%
“…The effect of cyclosporine and gemfibrozil on the disposition of rosuvastatin was investigated in this study using an advanced method in pigs, which enables in vivo pharmacokinetics to be assessed at multiple plasma sites simultaneously, along with direct monitoring of the excretion of rosuvastatin into bile and the upper part of the small intestine (Petri et al, 2006;Persson et al, 2007Persson et al, , 2008Sjödin et al, 2008). The pig is an appropriate animal for the investigation of drug disposition, as it is known to display high similarities with humans with regard to its gastrointestinal physiology and important transport and enzymatic proteins have been identified in pigs such as CYP3A4, CYP2E1, CYP2C, OATP1B1, OATP1A2, and MRP2 (Kararli, 1995;Lampen et al, 1995;Anzenbacher et al, 1998;Goh et al, 2002;Tang et al, 2004;Baranová et al, 2005;Upton, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…Second, the expression and activity of the major enzymes responsible for drug biotransformation are comparable with those in humans, thus making the pig a useful model for metabolic studies (Anzenbacher et al, 1998;Zuber et al, 2002). Less is known about the expression of transport proteins in pigs, although the pharmacokinetic properties of drugs known to be actively transported in humans (e.g., cyclosporine, digoxin, fexofenadine, verapamil, danazol) are similar (Petri et al, 2006;Tannergren et al, 2006;Persson et al, 2008). The possible use of porcine proximal tubular cells and brain capillary endothelial cells for mimicking drug transport in the human kidney and blood-brain barrier, respectively, is under investigation (Eisenblätter and Galla, 2002; Török et al, 2003;Schlatter et al, 2006).…”
mentioning
confidence: 99%