“…Also, in UND-assisted MOI modification, the strong turbulence force may break intramolecular hydrogen bond interactions, which lowers the α-helix content [23] , [43] . The steric hindrance induced by the covalent alteration of MOI may also reduce the hydrogen bond between MRN molecules, resulting in a decrease in a helical structure [39] . Surprisingly, the UMP/LBG group did not exhibit the lowest α-helix amount, even though it had the largest sonochemical effect.…”