Improved working memory performance following administration of a single dose of American ginseng (<scp><i>Panax quinquefolius</i> L.</scp>) to healthy middle‐age adults

Ossoukhova, Anastasia; Owen, Lauren; Savage, Karen; Meyer, M.; Ibarra, Alvin; Roller, Marc; Pipingas, Andrew; Wesnes, Keith; Scholey, Andrew

doi:10.1002/hup.2463

Cited by 47 publications

(40 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This led us to evaluate the effects of 200 mg of the same extract in healthy, middle‐aged adults. We again observed enhanced working memory in the 6 h following administration (Ossoukhova et al, 2015). A composite working memory battery was significantly improved and maximal 3 h post‐dose.…”

Section: Introductionsupporting

confidence: 62%

Effects ofPanax quinquefolius(American ginseng) on the steady state visually evoked potential during cognitive performance

White

Camfield

Ossoukhova

et al. 2020

Human Psychopharmacology

Self Cite

View full text Add to dashboard Cite

Objective To investigate the effects of acute Panax quinquefolius (American ginseng) administration on steady state visually evoked potentials (SSVEPs) during completion of working memory and continuous performance tasks. Methods A randomised, double‐blind, placebo controlled, balanced, cross‐over trial was conducted in middle‐aged volunteers aged between 40 and 60 years. Participants were administered 200 mg P. quinquefolius and placebo on two separate testing sessions. Six‐h post‐dose participants completed spatial working memory (SWM) and continuous performance (CP) tasks while SSVEP from a diffuse task‐irrelevant 13 Hz flicker was recorded. Results During SWM retrieval, P. quinquefolius was associated with significantly reduced prefrontal SSVEP latency. There were no significant treatment effects on CP nor behavioural performance of either task. Conclusions These findings provide preliminary evidence of increased recruitment of prefrontal brain regions during working memory processing following a single acute dose of P. quinquefolius.

show abstract

Section: Introductionsupporting

confidence: 62%

Effects ofPanax quinquefolius(American ginseng) on the steady state visually evoked potential during cognitive performance

White

Camfield

Ossoukhova

et al. 2020

Human Psychopharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Regarding the effect of P. ginseng on cognition, Geng et al (2010) published an extensive systematic review which included nine randomized, double-blind, placebo-controlled studies (eight of which enrolled healthy participants) and concluded there was no convincing evidence to support the cognitive enhancing effect of ginseng. Following this report, additional clinical studies in literature described the beneficial effects of Cereboost™ (100e400 mg per os) on the short-term working memory performance in both 52 middle-aged healthy adults (Ossoukhova et al, 2015) and 32 healthy young adults (Scholey et al, 2010). Although these Authors did not provide any direct evidence about the mechanism(s) underlying the nootropic effect of Cereboost™, they speculated a possible role for the activation of both cholinergic and dopaminergic brain systems and modulation of NO production.…”

Section: Clinical Studiesmentioning

confidence: 91%

Panax ginseng and Panax quinquefolius : From pharmacology to toxicology

Mancuso

Santangelo

2017

Food and Chemical Toxicology

280

140

View full text Add to dashboard Cite

The use of Panax ginseng and Panax quinquefolius in traditional Chinese medicine dates back to about 5000 years ago thanks to its several beneficial and healing properties. Over the past few years, extensive preclinical and clinical evidence in the scientific literature worldwide has supported the beneficial effects of P. ginseng and P. quinquefolius in significant central nervous system, metabolic, infectious and neoplastic diseases. There has been growing research on ginseng because of its favorable pharmacokinetics, including the intestinal biotransformation which is responsible for the processing of ginsenosides - contained in the roots or extracts of ginseng - into metabolites with high pharmacological activity and how such principles act on numerous cell targets. The aim of this review is to provide a simple and extensive overview of the pharmacokinetics and pharmacodynamics of P. ginseng and P. quinquefolius, focusing on the clinical evidence which has shown particular effectiveness in specific diseases, such as dementia, diabetes mellitus, respiratory infections, and cancer. Furthermore, the review will also provide data on toxicological factors to support the favorable safety profile of these medicinal plants.

show abstract

“…Rg1 can also improve nonspecific immunity in humans and promote the hematopoietic and immune function recovery of patients with bone marrow injury; thus, this molecule can be used to treat various immune and hematopoietic system diseases (Lee et al, 2004;Xu et al, 2012). Simultaneously, five clinical trials on the use of drugs containing Rg1 to treat vascular dementia, cognitive changes, Sjögren's syndrome, rheumatic diseases, and stroke, as well as a safety evaluation, have been registered on clinicaltrials.gov; three of these trials have completed recruitment, and the related results have been published; two have not yet completed subject recruitment (Sotaniemi et al, 1995;Ellis and Reddy, 2002;Scholey et al, 2010;Ossoukhova et al, 2015;Shin et al, 2016;Tian et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells

Liu

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Recently, breakthroughs have been made in the use of mesenchymal stem cells (MSCs) to treat various diseases. Several stem cell types have been authorized as drugs by the European Medicines Agency and the U.S. Food and Drug Administration. The Chinese official document "Notification of the management of stem cell clinical research (trial)" was also published in August 2015. Currently, China has approved 106 official stem cell clinical research filing agencies and 62 clinical research projects, which are mostly focused on MSC therapy. Hence, the optimization and development of stem cell drugs is imperative. During this process, maximizing MSC expansion, minimizing cell loss during MSC transplantation, improving the homing rate, precisely regulating the differentiation of MSCs, and reducing MSC senescence and apoptosis are major issues in MSC preclinical research. Similar to artemisinin extracted from the stems and leaves of Artemisia annua, ginsenoside Rg1 (Rg1) is purified from the root or stem of ginseng. In the human body, Rg1 regulates organ function, which is inseparable from its regulation of adult stem cells. Rg1 treatment may effectively regulate the proliferation, differentiation, senescence, and apoptosis of MSCs in different microenvironments in vitro or in vivo. In this review, we discuss recent advances in understanding the effect of Rg1 on MSCs and describe the issues that must be addressed and prospects regarding Rg1 regulation of MSCs in preclinical or clinical studies.

show abstract

Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle‐age adults

Abstract: These data confirm that P. quinquefolius can acutely benefit working memory and extend the age range of this effect to middle-aged individuals. These changes are unlikely to be underpinned by modulation of blood glucose in this population.

Cited by 47 publications

References 53 publications

Effects ofPanax quinquefolius(American ginseng) on the steady state visually evoked potential during cognitive performance

Effects ofPanax quinquefolius(American ginseng) on the steady state visually evoked potential during cognitive performance

Panax ginseng and Panax quinquefolius : From pharmacology to toxicology

Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells

Contact Info

Product

Resources

About