Improvement in antimicrobial properties of titanium by diethyl phosphite plasma-based surface modification

Can, Gizem Kaleli; Özgüzar, Hatice Ferda; Kahriman, Selahattin; Türkal, Miranda; Göçmen, Jülide Sedef; Yurtçu, Erkan; Mutlu, Mehmet

doi:10.1016/j.mtcomm.2020.101565

Cited by 12 publications

(8 citation statements)

References 41 publications

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“…Plasma-polymerized diethyl phosphite (DEP) coated titanium (pp(DEP)-Ti) substrates exhibited excellent cytocompatibility and anti-biofilm properties. The painted surfaces were found to be hydrophobic, and the in vitro studies showed the antibacterial and anticandidal nature of the coating against Staphylococcus aureus and Candida albicans cells, proving to have a promising potential in treating peri-implantitis [ 104 ]. A highly efficient anti-bacterial coating comprising phosphonate/active ester block copolymers (pDEMMP-b-pNHSMA) with identical phosphonate segments was reported.…”

Section: Antibacterial Coatings On Titanium Implantsmentioning

confidence: 99%

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

et al. 2022

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Titanium and its alloys are widely used as implant materials for biomedical devices owing to their high mechanical strength, biocompatibility, and corrosion resistance. However, there is a significant rise in implant-associated infections (IAIs) leading to revision surgeries, which are more complicated than the original replacement surgery. To reduce the risk of infections, numerous antibacterial agents, e.g., bioactive compounds, metal ions, nanoparticles, antimicrobial peptides, polymers, etc., have been incorporated on the surface of the titanium implant. Various coating methods and surface modification techniques, e.g., micro-arc oxidation (MAO), layer-by-layer (LbL) assembly, plasma electrolytic oxidation (PEO), anodization, magnetron sputtering, and spin coating, are exploited in the race to create a biocompatible, antibacterial titanium implant surface that can simultaneously promote tissue integration around the implant. The nature and surface morphology of implant coatings play an important role in bacterial inhibition and drug delivery. Surface modification of titanium implants with nanostructured materials, such as titanium nanotubes, enhances bone regeneration. Antimicrobial peptides loaded with antibiotics help to achieve sustained drug release and reduce the risk of antibiotic resistance. Additive manufacturing of patient-specific porous titanium implants will have a clear future direction in the development of antimicrobial titanium implants. In this review, a brief overview of the different types of coatings that are used to prevent implant-associated infections and the applications of 3D printing in the development of antibacterial titanium implants is presented.

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Section: Antibacterial Coatings On Titanium Implantsmentioning

confidence: 99%

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

et al. 2022

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“…Due to the wide use of titanium and its alloys in implant dentistry, surfaces coated or modified with inherent bactericidal agents are being continuously investigated to prevent or treat peri-implantitis. These bactericidal agents include totarol, zinc, copper, silver, peptides, graphene oxide, and polymeric coatings on titanium and its alloys. − Some of the other generic antibacterial strategies, not limited to titanium-based implants, are discussed in a recent review . The strategies have been classified as antifouling, release-killing, contact killing and intrinsic antibacterial activity of implant materials.…”

Section: Strategies To Reduce Bacterial Colonization On Titanium and ...mentioning

confidence: 99%

Preventing Peri-implantitis: The Quest for a Next Generation of Titanium Dental Implants

Hasan

Bright

Hayles

et al. 2022

ACS Biomater. Sci. Eng.

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Titanium and its alloys are frequently the biomaterial of choice for dental implant applications. Although titanium dental implants have been utilized for decades, there are yet unresolved issues pertaining to implant failure. Dental implant failure can arise either through wear and fatigue of the implant itself or peri-implant disease and subsequent host inflammation. In the present report, we provide a comprehensive review of titanium and its alloys in the context of dental implant material, and how surface properties influence the rate of bacterial colonization and peri-implant disease. Details are provided on the various periodontal pathogens implicated in peri-implantitis, their adhesive behavior, and how this relationship is governed by the implant surface properties. Issues of osteointegration and immunomodulation are also discussed in relation to titanium dental implants. Some impediments in the commercial translation for a novel titanium-based dental implant from “bench to bedside” are discussed. Numerous in vitro studies on novel materials, processing techniques, and methodologies performed on dental implants have been highlighted. The present report review that comprehensively compares the in vitro, in vivo, and clinical studies of titanium and its alloys for dental implants.

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“…A favorable aspect is that at least five of these reports also evaluated the human cell compatibility of the plasma polymers. [67][68][69]71,76] However, questions remain about whether one-step plasma polymer films will be sufficiently effective as a clinical infection control measure. With activity typically resulting in ~90% reduction in bacterial adhesion to surfaces, this must be considered against the perspective that microbial pathogens can number in the hundreds of thousands or in the millions, and are capable of exponential growth in a number of hours, the question is whether a 90% (log 1) reduction of attachment of pathogens would be a clinically relevant benchmark for the performance of such coatings.…”

Section: Plasma Polymers With Inherent Antimicrobial Propertiesmentioning

confidence: 99%

“…Kaleli‐Can et al deposited a plasma polymer coating from the precursor diethyl phosphite. [ 76 ] Using the JIS Z 2801 standard test for antimicrobial activity of plastics, antimicrobial results were reported for S. aureus and C. albicans . Compared to controls, antibacterial and antifungal performance was modest showing an ability to eliminate 150 CFU/ml for S. aureus and 60 CFU/mL for C. albicans .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Plasma polymerization for biomedical applications: A review

Coad

Favia

Vasilev

et al. 2022

Plasma Processes & Polymers

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Plasma polymers have long been of interest as thin film coatings on biomedical devices and products, to generate desirable surface properties for favorable biointerfacial interactions. Plasma polymers have also been used as platforms for the covalent immobilization of bioactive molecules. More recently, additional aspects have been investigated, such as selective prevention of adhesion of microbial pathogens, either via plasma polymers per se or including antimicrobial drugs. Plasma polymers have also been investigated for the release of silver ions and small organic molecules. Complementing lowpressure plasma approaches, processes at atmospheric pressure have attracted interest recently, including for nano/ biocomposite coatings. This contribution reviews the use of plasma polymers for intended biomedical applications, with a focus on more recent topic areas.

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Improvement in antimicrobial properties of titanium by diethyl phosphite plasma-based surface modification

Cited by 12 publications

References 41 publications

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

Preventing Peri-implantitis: The Quest for a Next Generation of Titanium Dental Implants

Plasma polymerization for biomedical applications: A review

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