Improvement in Cervical Dysplasia Associated with Folic Acid Therapy in Users of Oral Contraceptives

Butterworth, Charles E.; Hatch, Kenneth D.; Gore, Hazel; Mueller, Helmut; Krumdieck, Carlos L.

doi:10.1097/00006254-198211000-00017

Cited by 28 publications

(35 citation statements)

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“…We measured food intake and not serum levels of micronutrients, but neither this study nor some of the studies that also analysed serum levels of micro-nutrients could show any association to CIN 2-3 (Butterworth et al, 1992;Ho et al, 1998). Oral contraceptive pill intake has been postulated to induce a local folic acid deficiency and interfere with DNA synthesis, repair or somehow alter the susceptibility of cells to oncogenic viruses or chemical carcinogens and therefore be a risk factor for CIN (Butterworth et al, 1982;Harper et al, 1994). We found no association of folate intake with CIN 2-3 in the first place and also did not detect any interaction between folate intake and OC use.…”

Section: Discussionmentioning

confidence: 93%

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Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection

et al. 2000

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Smoking, nutrition, parity and oral contraceptive use have been reported as major environmental risk factors for cervical cancer. After the discovery of the very strong link between human papillomavirus (HPV) infection and cervical cancer, it is unclear whether the association of these environmental factors with cervical cancer reflect secondary associations attributable to confounding by HPV, if they are independent risk factors or whether they may act as cofactors to HPV infection in cervical carcinogenesis. To investigate this issue, we performed a population-based case–control study in the Västerbotten county of Northern Sweden of 137 women with high-grade cervical intra-epithelial neoplasia (CIN 2–3) and 253 healthy age-matched women. The women answered a 94-item questionnaire on diet, smoking, oral contraceptive use and sexual history and donated specimens for diagnosis of present HPV infection (nested polymerase chain reaction on cervical brush samples) and for past or present HPV infections (HPV seropositivity). The previously described protective effects of dietary micronutrients were not detected. Pregnancy appeared to be a risk factor in the multivariate analysis ( P < 0.0001). Prolonged oral contraceptive use and sexual history were associated with CIN 2–3 in univariate analysis, but these associations lost significance after taking HPV into account. Smoking was associated with CIN 2–3 (odds ratio (OR) 2.6, 95% confidence interval (CI) 1.7–4.0), the effect was dose-dependent ( P = 0.002) and the smoking-associated risk was not affected by adjusting for HPV, neither when adjusting for HPV DNA (OR 2.5, CI 1.3–4.9) nor when adjusting for HPV seropositivity (OR 3.0, CI 1.9–4.7). In conclusion, after taking HPV into account, smoking appeared to be the most significant environmental risk factor for cervical neoplasia. © 2000 Cancer Research Campaign

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Section: Discussionmentioning

confidence: 93%

“…Since OC use has been postulated to act via influencing the folate status (Butterworth et al, 1982;Harper et al, 1994) the possibility of an interaction between OC use and folate status was investigated. There was no OC-associated risk for CIN 2-3, neither among women with high, nor among women with low, folate intake (data not shown).…”

Section: Resultsmentioning

confidence: 99%

Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection

et al. 2000

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“…In particular, with respect to food classes consumption, it has been estimated that worldwide up to 50% of gastric cancer and up to 29% of colorectal cancer may be prevented with the increase in vegetable consumption and up to 45% of esophageal cancer and 50% of gastric cancers might have been prevented if fruit consumption had increased [64]. In fact, specific dietary components may play a role in cell cycle progression and proliferation [65,66]. Fruits and vegetables have been studied also with respect to CMM because of their content in apigenin and carotenoids; these last, together with retinoids, seem to be responsible for proliferation inhibition [65,66].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, specific dietary components may play a role in cell cycle progression and proliferation [65,66]. Fruits and vegetables have been studied also with respect to CMM because of their content in apigenin and carotenoids; these last, together with retinoids, seem to be responsible for proliferation inhibition [65,66]. Furthermore, dietary antioxidants, such as betacarotene and vitamins A, C and E which are contained in vegetables and fruits, may have a protective role in the early phase of CMM development [67].…”

Section: Discussionmentioning

confidence: 99%

Systematic review of studies investigating the association between dietary habits and cutaneous malignant melanoma

et al. 2015

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ObjectiveSeveral papers have dealt with diet as a risk factor for cutaneous malignant melanoma (CMM). This study is aimed at synthesizing available data on the topic. Study designA systematic review of observational studies assessing the association between dietary habits and CMM was performed. MethodsElectronic databases were used to identify eligible articles. Quality was evaluated through the NewCastle Ottawa scale. Case control and cohort studies assessing CMM occurrence in people with highest level of food and nutrient intake in comparison to lowest were considered eligible. Data from single studies were described qualitatively because combination of data was not possible. ResultsSixteen articles were selected. Cohort studies showed a better quality than case-control ones. Most studies did not figure out any significant association between foods intake and CMM, except for few evidence of a protective role associated to fish, vegetables and fruit. Risk reduction was shown 35-37%, 40-57% and 34-46% respectively across studies releasing significant results. Beta-carotene, vitamin A, retinol, vitamin E, and vitamin D showed a protective role in single studies with a risk reduction of 64%, 49%, 37-43%, 50-66% and 39% respectively. Conclusion 4A trend in the reduction of CMM risk with higher intake of fish, vegetables and fruits, as well as beta-carotene and vitamins A, E and D has been shown but further research is needed to provide decisive data.

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“…Case-control studies that estimated dietary folate intake have generally not been supportive of a protective role for folate [10][11][12][13], whereas case-control studies that used biochemical measures of folate status [14][15][16][17][18] were more convincing. Out of four randomized controlled trials using folic acid only one showed a significantly protective effect [19][20][21][22]. Folate and vitamin B 12 may have modulating effect in the risk cervical cancer development.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B and Antioxidants in Relation to Treatment Duration in Cervical Cancer Patients in Ibadan

Nwozo¹,

Am²,

Arinola³

2013

Intern Med

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Improvement in Cervical Dysplasia Associated with Folic Acid Therapy in Users of Oral Contraceptives

Cited by 28 publications

References 0 publications

Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection

Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection

Systematic review of studies investigating the association between dietary habits and cutaneous malignant melanoma

Vitamin B and Antioxidants in Relation to Treatment Duration in Cervical Cancer Patients in Ibadan

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