Improvement in Cranioplasty: Advanced Prosthesis Biomanufacturing

Jardini, André Luiz; Larosa, Maria Aparecida; Macedo, M.F.; Bernardes, Luís Fernando; Lambert, Carlos Salles; Zavaglia, Cecília Amélia de Carvalho; Filho, Rubens Maciel; Calderoni, Davi Reis; Ghizoni, Enrico; Kharmandayan, Paulo

doi:10.1016/j.procir.2015.11.017

Cited by 40 publications

(15 citation statements)

References 14 publications

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“…The non-randomized trial by Sumida et al [31] compared custom-made to prefabricated Ti scaffolds for guided bone regeneration of mandibular sites for dental implants. Their findings agree with other studies [35,102], in that the 3D-printed custom-made scaffolds have more ideal shape, better surgical handling, and considerably less intraoperative time, eliminating postoperative infections and mucosal rupture. The accuracy of the fabrication procedure leads to improved functional and aesthetic results [103].…”

Section: Operative Manipulation and Complicationssupporting

confidence: 90%

Applications of 3D printing on craniofacial bone repair: A systematic review

Maroulakos

Kamperos

Tayebi

et al. 2019

Journal of Dentistry

115

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Objectives Three-dimensional (3D) bioprinting, a method derived from additive manufacturing technology, is a recent and ongoing trend for the construction of 3D volumetric structures. The purpose of this systematic review is to summarize evidence from existing human and animal studies assessing the application of 3D printing on bone repair and regeneration in the craniofacial region. Data & sources A rigorous search of all relevant clinical trials and case series was performed, based on specific inclusion and exclusion criteria. The search was conducted in all available electronic databases and sources, supplemented by a manual search, in December 2017. Study selection 43 articles (6 human and 37 animal studies) fulfilled the criteria. The human studies included totally 81 patients with craniofacial bone defects. Titanium or hydroxylapatite scaffolds were most commonly implanted. The follow-up period ranged between 6 and 24 months. Bone repair was reported successful in nearly every case, with minimal complications. Also, animal intervention studies used biomaterials and cells in various combination, offering insights into the techniques, through histological, biochemical, histomorphometric and microcomputed tomographic findings. The results in both humans and animals, though promising, are yet to be verified for clinical impact. Conclusions Future research should be focused on well-designed clinical trials to confirm the short-and long-term efficacy of 3D printing strategies for craniofacial bone repair. Clinical significance Emerging 3D printing technology opens a new era for tissue engineering. Humans and animals on application of 3D printing for craniofacial bone repair showed promising results which will lead clinicians to investigate more thoroughly alternative therapeutic methods for craniofacial bone defects.

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Section: Operative Manipulation and Complicationssupporting

confidence: 90%

Applications of 3D printing on craniofacial bone repair: A systematic review

Maroulakos

Kamperos

Tayebi

et al. 2019

Journal of Dentistry

115

View full text Add to dashboard Cite

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“…10 Some researchers have tried reducing the stressshielding effect, by introducing porous structure in cranial implants but with no clear evidence and investigation on the behavior of the porous structure, porosity and its strength. 11,12 Porous implant provides interfacial adhesion between the bone and the implant, leading to effective fixation and shorter healing time. 13 Porous implants should have high porosity with sufficient space for cell adhesion and transportation of fluids.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Microstructure and mechanical properties of porous titanium structures fabricated by electron beam melting for cranial implants

Moiduddin

2018

Proc Inst Mech Eng H

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The traditional methods of metallic bone implants are often dense and suffer from adverse reactions, biomechanical mismatch and lack of adequate space for new bone tissue to grow into the implant. The objective of this study is to evaluate the customized porous cranial implant with mechanical properties closer to that of bone and to improve the aesthetic outcome in cranial surgery with precision fitting for a better quality of life. Two custom cranial implants (bulk and porous) are digitally designed based on the Digital Imaging and Communications in Medicine files and fabricated using additive manufacturing. Initially, the defective skull model and the implant were fabricated using fused deposition modeling for the purpose of dimensional validation. Subsequently, the implant was fabricated using titanium alloy (Ti6Al4V extra low interstitial) by electron beam melting technology. The electron beam melting-produced body diagonal node structure incorporated in cranial implant was evaluated based on its mechanical strength and structural characterization. The results show that the electron beam melting-produced porous cranial implants provide the necessary framework for the bone cells to grow into the pores and mimic the architecture and mechanical properties closer to the region of implantation. Scanning electron microscope and micro-computed tomography scanning confirm that the produced porous implants have a highly regular pattern of porous structure with a fully interconnected network channel without any internal defect and voids. The physical properties of the titanium porous structure, containing the compressive strength of 61.5 MPa and modulus of elasticity being 1.20 GPa, represent a promising means of reducing stiffness and stress-shielding effect on the surrounding bone. This study reveals that the use of porous structure in cranial reconstruction satisfies the need of lighter implants with an adequate mechanical strength and structural characteristics, thus restoring better functionality and aesthetic outcomes for the patients.

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“…Progress in medical imaging, computer-aided design, and rapid prototyping techniques have helped to design and manufacture models for anatomical structures and patient implant fabrication. [7] Presented the clinical use of rapid prototypes, 3D models, and pre-curved reconstruction plates for mandibular reconstruction after cancer resection has been approved. Describes a new approach using similar techniques in managing complex mandibular fractures.…”

Section: Literature Surveymentioning

confidence: 99%

“…[8] Presented a proposed methodology for designing and constructing a patient-specific transplant based on the patient's medical image data so that the methodology helps to investigate the match between medical data and the new design. [9] Presented AM advances applied to the structure and assembling of a bio model, actually, an embed for the careful remaking of a huge cranial imperfection. A progression of registered tomography information was acquired and programming was utilized to extricate the cranial geometry.…”

Section: Literature Surveymentioning

confidence: 99%

Integration of CAD/CAE/RP Environment for Developing a New Product in Medical Field

Allawy¹,

Abdulghafour²

2020

ETJ

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Reconstruction of the mandible after severe trauma is one of the most difficult challenges facing oral and maxillofacial surgery. The mandible is an essential element in the appearance of the human face that gives the distinctive shape of the face, holds. This paper aims to propose a methodology that allows the surgeon to perform virtual surgery by investing engineering programs to place the implant by default and with high accuracy within the mandible based on the patient's medical data. The current study involved a 35-year-old man suffering from a traffic accident in the mandible with multiple fractures of the facial bones. Basically, an identification of the steps required to perform virtual surgery and modeling images from the CBCT technology has been done by using the software proposed in the research. The implant model is designed as a mesh model, allowing the patient to return to a normal position. Moreover, an application of FEA procedures using the Solidworks simulation software to test and verify the mechanical properties of the final transplant.

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Improvement in Cranioplasty: Advanced Prosthesis Biomanufacturing

Cited by 40 publications

References 14 publications

Applications of 3D printing on craniofacial bone repair: A systematic review

Applications of 3D printing on craniofacial bone repair: A systematic review

RETRACTED: Microstructure and mechanical properties of porous titanium structures fabricated by electron beam melting for cranial implants

Integration of CAD/CAE/RP Environment for Developing a New Product in Medical Field

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