Improvement in Glycemic Control in Morbidly Obese Type 2 Diabetic Subjects by Gastric Stimulation

Abstract

The TANTALUS system is well tolerated in obese type 2 diabetic subjects. Gastric electrical stimulation can potentially improve glucose metabolism and induce weight loss in obese diabetic patients, who are not well controlled on oral antidiabetic therapy. Further evaluation is required to determine whether this effect is due to induced weight loss and/or to direct signal dependent mechanisms.

Modulacja kurczliwości żołądka — nowa metoda leczenia cukrzycy typu 2 u osób z otyłością

“…The majority of adverse events were unrelated to the device or procedure. Most of the procedure-related events were consistent with those commonly encountered in similar laparoscopic procedures [19,20,[23][24][25][26][27].…”

“…Bohdjalian A et al [23] Obese patients with type 2 diabetes previously treated with oral drugs and/or insulin, BMI 33.3-49.7 kg/m 2 , (24) Implantation of pulse generator, 1 year follow-up There were 18 adverse events related to the implant procedure or the device reported in 12 subjects. All were short lived and resolved with no sequelae.…”

“…Większość objawów niepożądanych nie była związana z procedurą lub działaniem urządzenia, a te zależne od procedury należały do typowych dla większości brzusznych zabiegów laparoskopowych [19,20,[23][24][25][26][27].…”

Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives

“…Two studies, one from TANTALUS ® [39] and the other from gastric pacing [40] , found lower ghrelin levels after device activation. However, three studies, two from IGS [41,42] and another TANTALUS ® [43] study, found no statistically significant changes in ghrelin levels.…”

“…Only one study [28,39] reported significant weight loss at both 6 and 12 mo. However, 6-mo weight loss was greater than that achieved at a later time period.…”