Improvement in mortality and retention among adult HIV‐infected patients in the first 12 months of antiretroviral therapy in Dodoma urban district,Tanzania.

Tweve, Escor N.; Kayabu, David; Nassari, Nahum O.; Todd, Jim

doi:10.1111/tmi.12488

Cited by 1 publication

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individuals initiating ART after 2007 in our cohort had higher mortality than those initiating ART earlier. This result contrast with findings from other HIV-1 studies, reporting a tremendous decline in mortality and LTFU with the scaling up of ART programs (12,29,30). One possible explanation for our finding could be the potential for the lower likelihood of being captured in programmatic databases for patients who started ART prior to 2007, and died or who were lost to follow up soon after entering care, compare to patients who survived.…”

Section: Discussioncontrasting

confidence: 99%

“…In addition, men were more likely to die than women in our cohort, as has been reported in ART-receiving HIV-1 infected individuals (10,13,14). Baseline clinical and laboratory characteristics have been identified as possible factors explaining this sex-difference in mortality in HIV-1 infected individuals (12,18–20,29). Similar associated factors were found in our study, especially the CD4 counts that were lower in men than in women at ART initiation, indicating higher rates of late presentation among men.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of sex and age on outcomes among HIV-2-infected patients starting antiretroviral therapy in West Africa

Tchounga

Hønge

Eholié

et al. 2016

Aids

View full text Add to dashboard Cite

Objectives HIV-2-infected individuals usually initiate antiretroviral therapy (ART) at an advanced age compared with HIV-1 patients, with a potential impact on treatment outcomes. This study aimed to investigate the effect of sex and age on mortality and loss to follow-up (LTFU) among HIV-2-infected individuals initiating ART. Methods Analyses were conducted using the database of the IeDEA–HIV-2 West Africa collaboration. LTFU was considered if the interval between the last visit and the closing date for this analysis was >180 days. Probability of death and LTFU were estimated with Kaplan-Meier methods. A Cox regression model was used to identify factors associated with death and LTFU over the first 24 months on ART. Results A total of 1,825 HIV-2-infected individuals including 60% women were considered for this analysis. The median age, baseline CD4 and follow-up duration were 45 years (IQR[38-52]), 185 cells/mm3 (IQR[95–297]) and 28.8 months (IQR[9.8–58.9]), respectively. Over the first 24 months, the mortality rate was 5.2 per100 pyo (95%CI[4.4-6.1]) and 469 (25.7%) were LTFU. Male sex (HR=1.9; 95%CI[1.4;2.8]), baseline CD4<100 cell/mm3 (HR=4.4 95%CI[1.7;11.1]; ref≥350 cell/mm3), haemoglobin 7.5–10g/dL (HR=2.4 95%CI[1.3;4.4]; ref≥12 g/dL); and body mass index <18 kg/m2 (HR=2.1 95%CI[1.3;3.4]; ref=18-25 kg/m2) were associated with higher mortality over the first 24 months. Similar associations were found for LTFU. Conclusion Mortality and LTFU are high among ART-receiving HIV-2-infected individuals and higher in men than in women. There is a critical need to further determine the causes of poor retention and implement sex specific solutions that improve outcomes in HIV-2 ART programs.

show abstract

Section: Discussioncontrasting

confidence: 99%