Improvement in Quality of Life of An Oncological Patient by Laser Phototherapy

Campos, Luana; Simões, Alyne; Sá, Pedro Henrique Rosário Nogueira; Eduardo, Carlos

doi:10.1089/pho.2008.2300

Cited by 68 publications

(82 citation statements)

References 19 publications

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“…The use of therapeutic laser in the present study showed positive outcomes and the efficacy of laser to prevent and treat OM in patients subjected to HSCT, chemotherapy and radiotherapy, in accordance with data found in the literature (8,(11)(12)(13)(14)(15)(16)18,20) and the results were similar to those obtained by Antunes et al (12). The outcomes of the present study add to the evidence that therapeutic laser can be an effective option for the prevention and treatment of OM in patients subjected to HSCT with the absence of adverse effects or discomfort, as suggested by other authors (11,13).…”

Section: Discussionsupporting

confidence: 92%

Use of therapeutic laser for prevention and treatment of oral mucositis

et al. 2009

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Oral mucositis (OM) affects patients who are submitted to hematopoietic stem cell transplantation (HSCT) due to high doses of chemotherapy and/or radiotherapy. The purpose of this investigation was to perform a comparative study of the frequency and evolution of OM among patients subjected to therapeutic laser and to the conventional therapy (use of mouthwash called "Mucositis Formula"). The patients were subjected to a myeloablative conditioning regimen before the allogeneic HSCT. Twenty-two patients were selected and divided into 2 groups: group I was irradiated with InGaAlP laser (660 nm) and GaAlAs laser (780 nm), 25 mW potency, 6.3J/ cm 2 dose, in 10-s irradiation time, followed to conventional treatment; group II was subjected only to the conventional treatment. Both World Health Organization (WHO) scale and the Oral Mucositis Assessment Scale (OMAS) were used to evaluate the results. Data were analyzed by the non-parametric Wilcoxon test, with p<0.05 considered as statistically significant. Group I presented a lower frequency of OM (p=0.02) and lower mean scores, according to WHO and OMAS scales (p<0.01 and p=0.01, respectively). In conclusion, laser reduced the frequency and severity of OM, suggesting that therapeutic laser can be used both as a new form of prevention and treatment of OM.

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Section: Discussionsupporting

confidence: 92%

Use of therapeutic laser for prevention and treatment of oral mucositis

et al. 2009

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“…LPT is based on nonthermal effects of light on biological tissues, and its use in the prevention and treatment of mucositis induced by antineoplastic treatment has presented promising results, especially in clinical studies (1,3,4,13). The effect of LPT is based on its ability to modulate several metabolic processes.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, Zanin et al (1) and Lopes et al (17) reported that in their studies all patients under RT who received LPT completed the planned RT treatment, whereas patients not treated with LPT had to interrupt the RT because of decreased immunity caused by secondary asthenia and deglutition difficulties, which impacted their survival. Several protocols have been used for treating oral mucositis and the observed results sometimes differ (1,3,4,13,16,17). It is necessary to standardize the protocols for prevention and treatment of this condition in order to make different studies comparable.…”

Section: Discussionmentioning

confidence: 99%

“…Discomfort or severe oral pain may be caused by oral mucositis, as well as difficulties on drinking, eating, swallowing and speaking, which impair patient's quality of life (1,3). It starts asymptomatic, later on, an erythema appears and it may be followed by erosion or ulceration of the oral mucosa.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies (3,4,6,7,10,11) have suggested that the use of LPT seems to reduce the severity of mucositis, providing comfort and better quality of life. Zanin et al (1) evaluated the effects of a 660-nm diode laser on the prevention and treatment of chemo-and radiotherapy-induced oral mucositis in patients with head and neck cancer.…”

Section: Introductionmentioning

confidence: 99%

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Laser phototherapy as a treatment for radiotherapy-induced oral mucositis

Lino

Carvalho

Oliveira³

et al. 2011

Braz. Dent. J.

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Oral mucositis is a harmful side effect of radiotherapy (RT) on the head and neck region. There are encouraging reports on the beneficial aspects of the use of laser light on the treatment of oral mucositis. This paper reports the efficacy of laser phototherapy (LPT) on the treatment of oral mucositis in a patient undergoing RT after surgical removal of a squamous cell carcinoma with osseous invasion of the maxilla. Palatal and commissural lesions were treated with l660 nm, 40 mW, ∅=4 mm 2 , in contact mode, 5 x 2.4 J/cm 2 per point, 14.4 J/cm 2 per session. For treating the lesion on the patient's nasal mucosa, LPT (∅=4 mm 2 , l780 nm, 70 mW, 3 x 2.1 J/cm 2 per point, 6.3 J/cm 2 per session, contact mode) was used on the external area of the nose. A single dose (2.4 J/cm 2 ) with the l660 nm laser, as described before, was applied on the entrance of each nostril. LPT was used 3 times/week during 4 weeks. Treatment results indicate that the use of LPT on oral mucositis was effective and allowed the patient to carry on the RT without interruption. However, long-term and controlled clinical trials are necessary to establish both preventive and curative protocols using LPT.

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