Improvement in sensitivity of radiochromic 3D dosimeter based on rigid polyurethane resin by incorporating tartrazine

Cho, Jin Dong; Son, Jaeman; Choi, Cheol Young; Kim, Jin Sung; Wu, Hong Gyun; Park, Jong Min; Kim, Jung-In

doi:10.1371/journal.pone.0230410

Cited by 4 publications

(11 citation statements)

References 43 publications

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“…Among them, part A and part B correspond to aliphatic diisocyanates and polymers with hydroxyl functional groups, respectively. 58 The urethane group (−NCO) in the hard chain reacts with the hydroxyl group (−OH) in the polyol to form a carbamic acid group (−NHCOO−), as shown in the reaction scheme in Figure 1b. The PUI sample with a thickness of 1 mm was cut into long strips to facilitate the analysis of its self-healing behavior.…”

Section: Resultsmentioning

confidence: 99%

“…The self-healing PU–IPDI film, denoted as PUI, contains an IPDI monomer, part A and part B. Among them, part A and part B correspond to aliphatic diisocyanates and polymers with hydroxyl functional groups, respectively . The urethane group (−NCO) in the hard chain reacts with the hydroxyl group (−OH) in the polyol to form a carbamic acid group (−NHCOO−), as shown in the reaction scheme in Figure b.…”

Section: Resultsmentioning

confidence: 99%

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A Transparent Self-Healing Polyurethane–Isophorone-Diisocyanate Elastomer Based on Hydrogen-Bonding Interactions

Lee

Kim

et al. 2022

ACS Appl. Polym. Mater.

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Self-healing elastomers that can repair physical damage and extend their service life in medium-and low-temperature environments have attracted considerable attention in the field of flexible materials. However, the self-healing polyurethane (PU) healing process reported in previous studies regularly needs to be supported by high heating temperature and long healing time. In this study, a simple method was developed to synthesize a self-healing PU film using isophorone diisocyanate (IPDI) and a transparent rubber solution. The high transmittance (89%) of the resulting polyurethane−isophorone-diisocyanate (PUI) film was confirmed by UV−vis spectroscopy. FT-IR spectroscopy revealed that the hydrogen bonds formed by the imino group and the C O bonds in IPDI and the transparent rubber facilitated the self-healing of the PUI composite film. The optical microscope observed that the self-healing PU can complete the self-healing of cracks in a short period. Moreover, a PUI film restored at 60 °C for 1 h withstood a load of 1 kg. Tensile tests showed that healing efficiencies of 82% and 99% were achieved by the PUI film healed at 60 °C for 1 and 2 h, respectively. A self-healing experiment conducted on a silver-nanowire/PUI-film system confirmed the synergistic recovery performance of PUI on a conductive coating. The self-healing PUI elastomers might have potential commercial prospects in transparent coatings, self-healing antibacterial films, robotic skins, and flexible electronics.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Transparent Self-Healing Polyurethane–Isophorone-Diisocyanate Elastomer Based on Hydrogen-Bonding Interactions

Lee

Kim

et al. 2022

ACS Appl. Polym. Mater.

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“…The RPD has a density of 1.053 g/cm 3 , an effective atomic number of 11.1, and a dose sensitivity of 0.1010 Gy, whereas the PRE-SAGE® dosimeter has a density of 1.048 g/cm 3 , an effective atomic number of 7.45, and a dose sensitivity of 0.0089 Gy 1 . 35,41 The manufacturing process consisted of the following: (1) Part B was completely mixed with reporter chemical, radical initiator, solvents, and yellow dye; (2) Part A was then put into Part B, which was vigorously mixed;…”

Section: Solid Polyurethane-based Dosimeter Fabricationmentioning

confidence: 99%

Development of a quasi‐3D dosimeter using radiochromic plastic for patient‐specific quality assurance

et al. 2023

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BackgroundPatient‐specific QA verification ensures patient safety and treatment by verifying radiation delivery and dose calculations in treatment plans for errors. However, a two‐dimensional (2D) dose distribution is insufficient for detecting information on the three‐dimensional (3D) dose delivered to the patient. In addition, 3D radiochromic plastic dosimeters (RPDs) such as PRESAGE® represent the volume effect in which the dosimeters have different sensitivities according to the size of the dosimeters. Therefore, to solve the volume effect, a Quasi‐3D dosimetry system was proposed to perform patient‐specific QA using predetermined‐sized and multiple RPDs.PurposeFor patient‐specific quality assurance (QA) in radiation treatment, this study aims to assess a quasi‐3D dosimetry system using an RPD.MethodsGamma analysis was performed to verify the agreement between the measured and estimated dose distributions of intensity‐modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT). We fabricated cylindrical RPDs and a quasi‐3D dosimetry phantom. A practicability test for a pancreatic patient utilized a quasi‐3D dosimetry device, an in‐house RPD, and a quasi‐3D phantom. The dose distribution of the VMAT design dictated the placement of nine RPDs. Moreover, a 2D diode array detector was used for 2D gamma analysis (MapCHECK2). The patient‐specific QA was performed for IMRT, VMAT, and stereotactic ablative radiotherapy (SABR) in 20 prostate and head‐and‐neck patients. For each patient, six RPDs were positioned according to the dose distribution. VMAT SABR and IMRT/VMAT plans employed a 2%/2 mm gamma criterion, whereas IMRT/VMAT plans used a 3%/2 mm gamma criterion, a 10% threshold value, and a 90% passing rate tolerance. 3D gamma analysis was conducted using the 3D Slicer software.ResultsThe average gamma passing rates with 2%/2 mm and 3%/3 mm criteria for relative dose distribution were 91.6% ± 1.4% and 99.4% ± 0.7% for the 3D gamma analysis using the quasi‐3D dosimetry system, respectively, and 97.5% and 99.3% for 2D gamma analysis using MapCHECK2, respectively. The 3D gamma analysis for patient‐specific QA of 20 patients showed passing rates of over 90% with 2%/2 mm, 3%/2 mm, and 3%/3 mm criteria.ConclusionsThe quasi‐3D dosimetry system was evaluated by performing patient‐specific QAs with RPDs and quasi‐3D phantom. The gamma indices for all RPDs showed more than 90% for 2%/2 mm, 3%/2 mm, and 3%/3 mm criteria. We verified the feasibility of a quasi‐3D dosimetry system by performing the conventional patient‐specific QA with the quasi‐3D dosimeters.

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“…A recent study demonstrated that PRESAGE with low Shore hardness presents lower sensitivity than PRESAGE with high Shore hardness. The study shows that the sensitivity of PRESAGE with high Shore hardness further increased by 36.6% upon incorporation with tartrazine [ 98 ]. However, PRESAGE exhibits a high effective atomic number, which compromised its water equivalency.…”

Section: Sensitivity and Linearity Of Presagementioning

confidence: 99%

“…Thus, the chemical reaction occurred at a longer period in the PRESAGE, which yielded a high Polymers 2022, 14, 2887 14 of 27 dose response. A recent study demonstrated that the incorporation of tartrazine did not influence the dose-rate dependency of PRESAGE [98]. The silicone-based radiochromic dosimeter has been developed and shows insignificant dose-rate dependency [110].…”

Section: The Dose Rate Dependencymentioning

confidence: 99%

A Review of PRESAGE Radiochromic Polymer and the Compositions for Application in Radiotherapy Dosimetry

et al. 2022

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Recent advances in radiotherapy technology and techniques have allowed a highly conformal radiation to be delivered to the tumour target inside the body for cancer treatment. A three-dimensional (3D) dosimetry system is required to verify the accuracy of the complex treatment delivery. A 3D dosimeter based on the radiochromic response of a polymer towards ionising radiation has been introduced as the PRESAGE dosimeter. The polyurethane dosimeter matrix is combined with a leuco-dye and a free radical initiator, whose colour changes in proportion to the radiation dose. In the previous decade, PRESAGE gained improvement and enhancement as a 3D dosimeter. Notably, PRESAGE overcomes the limitations of its predecessors, the Fricke gel and the polymer gel dosimeters, which are challenging to fabricate and read out, sensitive to oxygen, and sensitive to diffusion. This article aims to review the characteristics of the radiochromic dosimeter and its clinical applications. The formulation of PRESAGE shows a delicate balance between the number of radical initiators, metal compounds, and catalysts to achieve stability, optimal sensitivity, and water equivalency. The applications of PRESAGE in advanced radiotherapy treatment verifications are also discussed.

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Improvement in sensitivity of radiochromic 3D dosimeter based on rigid polyurethane resin by incorporating tartrazine

Cited by 4 publications

References 43 publications

A Transparent Self-Healing Polyurethane–Isophorone-Diisocyanate Elastomer Based on Hydrogen-Bonding Interactions

A Transparent Self-Healing Polyurethane–Isophorone-Diisocyanate Elastomer Based on Hydrogen-Bonding Interactions

Development of a quasi‐3D dosimeter using radiochromic plastic for patient‐specific quality assurance

A Review of PRESAGE Radiochromic Polymer and the Compositions for Application in Radiotherapy Dosimetry

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